Document Detail

Conditions of bifidobacterial colonization in preterm infants: a prospective analysis.
MedLine Citation:
PMID:  17460489     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Premature birth results in a delayed and abnormal qualitative pattern of gut colonization. This abnormal pattern is thought to affect intestinal development and contribute to a higher risk of gastrointestinal infectious diseases such as neonatal necrotizing enterocolitis (NEC). In particular, bifidobacteria are thought to play a major role. We therefore studied bifidobacterial colonization in preterm infants during the first month of life. PATIENTS AND METHODS: Fecal samples were prospectively analyzed in 52 infants born at a gestational age ranging from 30 to 35 weeks fed with a preterm formula alone and, in 18, with their mother's milk. Fecal samples were collected twice per week during the hospital stay. Bifidobacterial colonization was analyzed with culture and a molecular method. RESULTS: Bifidobacterial colonization occurred in 18 infants at a median age of 11 days, always greater than the corrected mean gestational age of 35.4 weeks (SD, 0.9) and greater than 34 weeks for 16 of 18. Colonization by bifidobacteria was affected by neither birthweight nor mode of delivery nor antibiotics given to the mother or infant. In contrast, birth gestational age had a significant impact on colonization by bifidobacteria (P < 0.05), which always occurred in children born at a birth gestational age greater than 32.9 weeks (P < 0.05). CONCLUSIONS: Birth gestational age seems to act as a major determinant of bifidobacterial colonization in the premature infant, suggesting the role of gut maturation, a finding that should probably be taken into account in manipulations of the gut flora aimed at reducing NEC.
Marie-José Butel; Antonia Suau; Florence Campeotto; Fabien Magne; Julio Aires; Laurent Ferraris; Nicolas Kalach; Bernard Leroux; Christophe Dupont
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  44     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-26     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-82     Citation Subset:  IM    
Department of Microbiology, EA 4065, Faculty of Pharmaceutical and Biological Sciences, Université Paris Descartes, Paris, France.
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MeSH Terms
Bifidobacteriales Infections / microbiology*
Child Development* / physiology
Feces / microbiology
Gestational Age
Infant, Newborn
Intestines / microbiology*,  physiology
Premature Birth / microbiology*
Prospective Studies

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