Document Detail

Conditions associated with very low values of glycohaemoglobin measured by an HPLC method.
MedLine Citation:
PMID:  15047733     Owner:  NLM     Status:  MEDLINE    
AIMS: To identify the causes of very low glycohaemoglobin (GHb) values in a sample of patients with diabetes in southern Brazil using high performance liquid chromatography.
METHODS: Between August 1996 and December 2001 all samples from patients with diabetes at a university hospital with GHb values below the reference range (4.7-6.0% HbA(1c)) were submitted to cellulose acetate electrophoresis. Medical records were reviewed to identify conditions that might be associated with these low values.
RESULTS: Among 29 657 samples analysed, 130 patients had GHb < 4.7%. Seventy three patients (56%) were heterozygous for HbS, HbC, or HbD (19 black, two mulatto, and 52 white patients). The other 57 patients (44%) without Hb variants had low haematocrit and haemoglobin values (42 patients) or other conditions such as pregnancy, lipaemia, malignancy, cirrhosis, acetylsalicylic acid use, and absence of diabetes (15 patients).
CONCLUSIONS: The presence of an Hb variant may falsely lower GHb measurements. However, anaemia is also a source of negative interference. The haematological status should be considered for the correct interpretation of GHb results.
J L Camargo; J L Gross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  57     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-05-13     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  AIM; IM    
Clinical Pathology Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
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MeSH Terms
Aged, 80 and over
Anemia / blood
Chromatography, High Pressure Liquid / methods
Diabetes Mellitus / blood*
Hemoglobin A / analysis
Hemoglobin A, Glycosylated / analysis*
Middle Aged
Sensitivity and Specificity
Statistics, Nonparametric
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 9034-51-9/Hemoglobin A
Comment In:
J Clin Pathol. 2004 Apr;57(4):344-5   [PMID:  15047732 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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