| Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male. | |
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MedLine Citation:
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PMID: 15609287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia. |
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Authors:
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Eriko Sada; Hideho Henzan; Ryoko Ohtani; Ken Takase; Toshihiro Miyamoto; Takahiro Fukuda; Koji Nagafuji; Keita Yamauchi; Yasushi Takamatsu; Shoichi Inaba; Mine Harada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 78 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-23 Completed Date: 2005-02-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 55-8 Citation Subset: IM |
Affiliation:
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Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Busulfan / administration & dosage*, therapeutic use Drug Delivery Systems Humans Immunosuppressive Agents / administration & dosage*, therapeutic use Leukemia, Myeloid, Acute / genetics*, surgery* Male Peripheral Blood Stem Cell Transplantation* Transplantation Conditioning* Transplantation, Autologous XYY Karyotype* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 55-98-1/Busulfan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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