| 'Conditioning' the heart during surgery. | |
| | |
MedLine Citation:
|
PMID: 19324569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Coronary heart disease (CHD) is the leading cause of death worldwide. Coronary artery bypass graft (CABG) surgery remains the procedure of choice for coronary artery revascularisation in a large number of patients with severe CHD. However, the profile of patients undergoing CABG surgery is changing with increasingly higher-risk patients being operated upon, resulting in significant morbidity and mortality in this patient group. Myocardial injury sustained during cardiac surgery, most of which can be attributed to acute myocardial ischaemia-reperfusion injury, is associated with worse short-term and long-term clinical outcomes. Clearly, new treatment strategies are required to protect the heart during cardiac surgery in terms of reducing myocardial injury and preserving left ventricular systolic function, such that clinical outcomes can be improved. 'Conditioning' the heart to harness its endogenous cardioprotective capabilities using either brief ischaemia or pharmacological agents, provides a potentially novel approach to myocardial protection during cardiac surgery, and is the subject of this review article. |
| | |
Authors:
|
Vinod Venugopal; Andrew Ludman; Derek M Yellon; Derek J Hausenloy |
Related Documents
:
|
16352029 - Current status of minimally invasive coronary artery bypass grafting in china. 18778949 - The chinese coronary artery bypass grafting registry study: how well does the euroscore... 20487339 - Low-risk profile for malignant ventricular arrhythmias and sudden cardiac death after s... 16286279 - Using the bilateral internal mammary artery in the left or right coronary artery system... 11273909 - Apolipoprotein e polymorphisms and age at first coronary artery bypass graft. 17174559 - The effect of sodium nitroprusside infusion on renal function during reperfusion period... 14740689 - Cardioplegia and myocardial preservation during cardiopulmonary bypass. 8859009 - Proarrhythmic actions of flecainide in an isolated tissue model of ischemia and reperfu... 10598969 - Initial clinical experience with a fully automatic in-hospital external cardioverter de... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-03-25 |
Journal Detail:
|
Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 35 ISSN: 1873-734X ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-25 Completed Date: 2009-07-15 Revised Date: 2010-03-29 |
Medline Journal Info:
|
Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: 977-87 Citation Subset: IM |
Affiliation:
|
The Hatter Cardiovascular Institute, University College London Hospital, 67 Chenies Mews, London WC1E 6HX, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cardiotonic Agents
/
therapeutic use Coronary Artery Bypass / adverse effects*, methods Coronary Disease / surgery* Heart Arrest, Induced / methods Humans Ischemic Preconditioning, Myocardial / methods* Myocardial Reperfusion Injury / etiology, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
|
//British Heart Foundation; //Department of Health |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents |
| Comments/Corrections | |
Comment In:
|
Eur J Cardiothorac Surg. 2010 Apr;37(4):982-3; author reply 983
[PMID:
19853466
]
|
Erratum In:
|
Eur J Cardiothorac Surg. 2009 Sep;36(3):608 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early Masaoka stage and complete resection is important for prognosis of thymic carcinoma: a 20-year...
Next Document: Hybrid approach as bridge to biventricular repair in a neonate with critical aortic stenosis and bor...