Document Detail

Conditioned taste aversions produced by nicotine in Roman High and Low Avoidance strains of rats.
MedLine Citation:
PMID:  3131799     Owner:  NLM     Status:  MEDLINE    
Rats of the RHA/iop and RLA/iop strains have been compared in a conditioned taste aversion procedure using nicotine (0.4 mg/kg SC) as the UCS. The procedure utilised a balanced, within-subject design for assessing discriminative aversions to drug- and saline-paired flavoured solutions. Nicotine produced clear aversions in both strains and there were no detectable differences in acquisition. During extinction, rats of the RHA/iop strain consumed more of the drug-paired flavoured solution than rats of the RLA/iop strain, and this difference became greater as the number of extinction trials proceeded. Differences in total fluid intake were too small to account for these effects that were also shown by changes in proportional intake when both flavoured solutions were presented simultaneously. Aversion was, therefore, rather weaker in RHA/iop rats than in RLA/iop rats. These results suggest that rats of the two strains do not differ in "learning ability" in a general way, and support interpretations based on differences in emotionality.
M J Durcan; H S Garcha; I P Stolerman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  94     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-14     Completed Date:  1988-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  532-5     Citation Subset:  IM    
Department of Pharmacology, Institute of Psychiatry, London, UK.
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MeSH Terms
Avoidance Learning / drug effects*
Conditioning (Psychology) / drug effects*
Discrimination (Psychology) / drug effects
Nicotine / pharmacology*
Rats, Inbred Strains
Species Specificity
Reg. No./Substance:

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