Document Detail

Conditioned taste aversion as a function of age in mature male rats.
MedLine Citation:
PMID:  7389781     Owner:  NLM     Status:  MEDLINE    
Experimental groups of young mature (90-120 days), mature (365-395 days), and aged (730-760 days) Fischer-344 rats were allowed to drink a saccharin solution followed by lithium chloride toxicosis initiated at one of three intervals, either 15, 60, or 240 minutes. Control groups were given saline placebos according to the same schedule. In a preference test conducted 48 hours after conditioning, there was little evidence of age differences in the acquisition of a saccharin aversion. Age differences were noted in the extinction of the aversion which was tested by monitoring preference over a period of 32 days of continuous access to saccharin and water. Older animals tended to show greater resistance to extinction.
D K Ingram; L J Peacock
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental aging research     Volume:  6     ISSN:  0361-073X     ISO Abbreviation:  Exp Aging Res     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  7603335     Medline TA:  Exp Aging Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-23     Citation Subset:  IM    
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MeSH Terms
Avoidance Learning*
Conditioning, Classical*
Extinction, Psychological
Lithium / toxicity
Rats, Inbred F344
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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