Document Detail

Conditioned inhibition of cyclophosphamide-induced taste aversion.
MedLine Citation:
PMID:  12038496     Owner:  NLM     Status:  MEDLINE    
Rats in an experimental group received trials during which 1 flavor (saccharin) was always followed by cyclophosphamide, an immunosuppressive drug, but another (vanilla) was not. An unconditioned stimulus-only group served as a control. Flavor-preference tests revealed that conditioned excitation and conditioned inhibition occurred in the conditioned group subjects but not in the control group subjects. This demonstration suggests that a conditioned inhibitor might be used to modify conditioned and unconditioned immune system functions, for example, natural killer-cell activity.
Joseph V Lambert; Wayne G Whitehouse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general psychology     Volume:  129     ISSN:  0022-1309     ISO Abbreviation:  J Gen Psychol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-05-31     Completed Date:  2002-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985111R     Medline TA:  J Gen Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-75     Citation Subset:  IM    
Department of Social Sciences, University of the Sciences in Philadelphia, PA 19104, USA.
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MeSH Terms
Analysis of Variance
Conditioning, Classical*
Depression / immunology
Immunosuppressive Agents*
Inhibition (Psychology)*
Random Allocation
Rats, Sprague-Dawley
Statistics, Nonparametric
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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