Document Detail

Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats.
MedLine Citation:
PMID:  15598142     Owner:  NLM     Status:  MEDLINE    
Food-reinforced conditioned activity and instrumental responding were measured in rats after 50 weeks of continuous access to a cocaine-saccharin solution in their home cages. The elevation of conditioned activity produced by acute access to the cocaine-saccharin solution in the home cage during testing was abolished by long-term preexposure to the cocaine solution, an effect that was reversed by systemic administration of cocaine immediately prior to testing. By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement.
Felicity J Miles; Barry J Everitt; Jeffrey W Dalley; Anthony Dickinson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  118     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-15     Completed Date:  2005-02-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1331-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Behavior, Animal
Cocaine / administration & dosage,  pharmacology*
Conditioning (Psychology) / drug effects*
Conditioning, Operant / drug effects*
Corpus Striatum / metabolism
Dopamine / metabolism
Dopamine Uptake Inhibitors / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Prefrontal Cortex / metabolism
Reinforcement (Psychology)*
Reinforcement Schedule
Saccharin / administration & dosage
Self Administration / methods
Serotonin / metabolism
Time Factors
Grant Support
G9537855//Medical Research Council
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 333DO1RDJY/Serotonin; FST467XS7D/Saccharin; I5Y540LHVR/Cocaine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intra-BLA or intra-NAc infusions of the dopamine D3 receptor partial agonist, BP 897, block intra-NA...
Next Document:  Chronic oral estrogen affects memory and neurochemistry in middle-aged female mice.