| Conditional risk factors in men with previous myocardial infarction: relevance of C3 and homocysteine. | |
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MedLine Citation:
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PMID: 11712826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To establish which traditional and conditional risk factors were effectively treated, and which remained active, in patients with previous myocardial infarction (PMI). METHODS AND RESULTS: In 47 PMI patients recently submitted to cardiological assessment and in 42 controls (50-70 years old men), traditional risk factors (total cholesterol, high-density lipoprotein cholesterol, blood glucose, blood pressure, cigarette smoking and body mass index) and the following variables were measured: fibrinogen, plasminogen activator inhibitor-1 (PAI-1), lipoprotein(a) [Lp(a)], total homocysteine, plasma folates, vitamin B12, high sensitivity C-reactive protein and C3 complement. Most patients were taking beta-blockers, ACE inhibitors and statins. Accordingly, patients had lower blood pressure and cholesterol values than controls. Moreover, they consumed less alcohol and coffee and did not differ from controls in cigarette smoking and body mass index. Conversely, patients had higher levels of homocysteine, fibrinogen, C3 complement and Lp(a), although of these factors only C3 and homocysteine remained significantly associated with PMI in multivariate analysis. C-reactive protein, PAI-1 and especially C3 often correlated with traditional risk factors in controls, but these correlations tended to disappear or reverse in PMI patients. Fibrinogen inversely correlated with alcohol consumption. Homocysteine correlated (inversely) with plasma folates only. Lp(a) did not correlate with any variable. CONCLUSIONS: Forty-seven patients with previous myocardial infarction displayed an excellent control of traditional risk factors, but they had higher mean C3 and homocysteine levels than the control group. |
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Authors:
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A Muscari; M C Mele; L Bastagli; G Poggiopollini; V Tomassetti; G Drago; C Legnani; A Barini; O Cappelletti; P Boni; P Puddu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cardiologica Volume: 56 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-19 Completed Date: 2002-03-01 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 303-11 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy. amuscari@med.unibo.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Complement C3 / metabolism* Homocysteine / blood* Humans Middle Aged Myocardial Infarction / blood*, etiology* Risk Factors Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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