| Conditional and Marginal Estimates in Case-Control Family Data - Extensions and Sensitivity Analyses. | |
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MedLine Citation:
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PMID: 23002315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This work considers two specific estimation techniques for the family specific proportional hazards model and for the population-averaged proportional hazards model. So far, these two estimation procedures were presented and studied under the gamma frailty distribution mainly because of its simple interpretation and mathematical tractability. Modifications of both procedures for other frailty distributions, such as inverse Gaussian, positive stable and a specific case of discrete distribution, are presented. By extensive simulations, it is shown that under the family specific proportional hazards model, the gamma frailty model appears to be robust to frailty distribution misspecification in both bias and efficiency loss in the marginal parameters. The population-averaged proportional hazards model, is found to be robust under the gamma frailty model misspecification only under moderate or weak dependency within cluster members. |
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Authors:
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Malka Gorfine; Rottem De-Picciotto; Li Hsu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-5 |
Journal Detail:
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Title: Journal of statistical computation and simulation Volume: 82 ISSN: 1563-5163 ISO Abbreviation: J Stat Comput Simul Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-9-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9880627 Medline TA: J Stat Comput Simul Country: - |
Other Details:
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Languages: ENG Pagination: 1449-1470 Citation Subset: - |
Affiliation:
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Faculty of Industrial Engineering and Management, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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