Document Detail

Conditional and Marginal Estimates in Case-Control Family Data - Extensions and Sensitivity Analyses.
MedLine Citation:
PMID:  23002315     Owner:  NLM     Status:  Publisher    
This work considers two specific estimation techniques for the family specific proportional hazards model and for the population-averaged proportional hazards model. So far, these two estimation procedures were presented and studied under the gamma frailty distribution mainly because of its simple interpretation and mathematical tractability. Modifications of both procedures for other frailty distributions, such as inverse Gaussian, positive stable and a specific case of discrete distribution, are presented. By extensive simulations, it is shown that under the family specific proportional hazards model, the gamma frailty model appears to be robust to frailty distribution misspecification in both bias and efficiency loss in the marginal parameters. The population-averaged proportional hazards model, is found to be robust under the gamma frailty model misspecification only under moderate or weak dependency within cluster members.
Malka Gorfine; Rottem De-Picciotto; Li Hsu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-5
Journal Detail:
Title:  Journal of statistical computation and simulation     Volume:  82     ISSN:  1563-5163     ISO Abbreviation:  J Stat Comput Simul     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9880627     Medline TA:  J Stat Comput Simul     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1449-1470     Citation Subset:  -    
Faculty of Industrial Engineering and Management, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel.
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