Document Detail

Condensin, chromatin crossbarring and chromosome condensation.
MedLine Citation:
PMID:  23218009     Owner:  NLM     Status:  In-Data-Review    
The processes underlying the large-scale reorganisation of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosome segregation during cell division still remain obscure. The chromosomal condensin complex is a major molecular effector of chromosome condensation and segregation in diverse organisms ranging from bacteria to humans. Condensin is a large, evolutionarily conserved, multisubunit protein assembly composed of dimers of the structural maintenance of chromosomes (SMC) family of ATPases, clasped into topologically closed rings by accessory subunits. Condensin binds to DNA dynamically, in a poorly understood cycle of ATP-modulated conformational changes, and exhibits the ability to positively supercoil DNA. During mitosis, condensin is phosphorylated by the cyclin-dependent kinase (CDK), Polo and Aurora B kinases in a manner that correlates with changes in its localisation, dynamics and supercoiling activity. Here we review the reported architecture, biochemical activities and regulators of condensin. We compare models of bacterial and eukaryotic condensins in order to uncover conserved mechanistic principles of condensin action and to propose a model for mitotic chromosome condensation.
Rahul Thadani; Frank Uhlmann; Sebastian Heeger
Related Documents :
22296109 - Optimisation of mesenchymal stromal cells karyotyping analysis: implications for clinic...
24260669 - Identifying parental chromosomes and genomic rearrangements in animal hybrid complexes ...
24758149 - Secondary structure stretched forms of long intron rna products from the view point of ...
23652939 - Mixed gonadal dysgenesis in a patient with de novo tas(y;19)(p11.3;q13.4) and 45,x mosa...
504639 - Hemophilia and the female: considerations for the radiologist.
11272649 - A self-fertile species of steinernema from indonesia: further evidence of convergent ev...
9134019 - Chromosome aberrations in human lymphocytes analysed by fluorescence in situ hybridizat...
15566469 - Prnp polymorphisms in chinese ovine, caprine and bovine breeds.
1677599 - No genetic linkage detected for schizophrenia to xq27-q28.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current biology : CB     Volume:  22     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R1012-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evolution of gene regulation: hybrid networks breed diversity.
Next Document:  Pygmy mole crickets jump from water.