Document Detail


Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice.
MedLine Citation:
PMID:  23153355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traumatic brain injury (TBI) may involve diverse injury mechanisms (e.g., focal impact vs. diffuse impact loading). Putative therapies developed in TBI models featuring a single injury mechanism may fail in clinical trials if the model does not fully replicate multiple injury subtypes, which may occur concomitantly in a given patient. We report development and characterization of a mixed contusion/concussion TBI model in mice using controlled cortical impact (CCI; 0.6 mm depth, 6 m/sec) and a closed head injury (CHI) model at one of two levels of injury (53 vs. 83 g weight drop from 66 in). Compared with CCI or CHI alone, sequential CCI-CHI produced additive effects on loss of consciousness (p<0.001), acute cell death (p<0.05), and 12-day lesion size (p<0.05) but not brain edema or 48-h contusion volume. Additive effects of CHI and CCI on post-injury motor (p<0.05) and cognitive (p<0.005) impairment were observed with sequential CCI-CHI (83 g). The data suggest that concussive forces, which in isolation do not induce histopathological damage, exacerbate histopathology and functional outcome after cerebral contusion. Sequential CHI-CCI may model complex injury mechanisms that occur in some patients with TBI and may prove useful for testing putative therapies.
Authors:
Heda R Dapul; Juyeon Park; Jimmy Zhang; Christopher Lee; Ali DanEshmand; Josephine Lok; Cenk Ayata; Tory Gray; Allison Scalzo; Jianhua Qiu; Eng H Lo; Michael J Whalen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-20
Journal Detail:
Title:  Journal of neurotrauma     Volume:  30     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-08-13     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Concussion / complications,  pathology*
Brain Injuries / complications,  pathology*
Disease Models, Animal*
Male
Maze Learning
Mice
Mice, Inbred C57BL
Recovery of Function*
Grant Support
ID/Acronym/Agency:
1R21NS075226/NS/NINDS NIH HHS; R01NS047447/NS/NINDS NIH HHS; R01NS064545/NS/NINDS NIH HHS; R21 NS075226/NS/NINDS NIH HHS
Comments/Corrections

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