Document Detail

Concurrent muscarinic and beta-adrenergic blockade in rats impairs place-learning in a water maze and retention of inhibitory avoidance.
MedLine Citation:
PMID:  2161697     Owner:  NLM     Status:  MEDLINE    
These experiments examined the effects of separate and concurrent muscarinic cholinergic and beta-adrenergic blockade on inhibitory (passive) avoidance performance and spatial learning in the Morris water maze. Pretraining systemic administration of either scopolamine (0.3 or 1.0 mg/kg) or propranolol (3.0 or 10.0 mg/kg) had no significant effect on one-day retention of step-through inhibitory avoidance training. Similarly, pretraining administration of either 0.3 mg/kg scopolamine or 10 mg/kg propranolol did not affect spatial learning in the Morris water maze. However, combined administration of scopolamine and 10.0 mg/kg of propranolol impaired performance on these tasks. These findings further support a role for interactions between norepinephrine and acetylcholine in the modulation of learning and memory and implicate the participation of beta-adrenergic mechanisms in this interaction. Because cholinergic and noradrenergic deterioration is found in aging and Alzheimer's disease, these results also have implications regarding the role of age-related noradrenergic and cholinergic dysfunction in cognitive decline.
M W Decker; T M Gill; J L McGaugh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  513     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-17     Completed Date:  1990-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Department of Psychobiology, University of California, Irvine 92717.
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MeSH Terms
Avoidance Learning / drug effects*
Memory / drug effects*
Propranolol / pharmacology*
Rats, Inbred Strains
Receptors, Adrenergic, beta / drug effects,  physiology*
Receptors, Muscarinic / drug effects,  physiology*
Scopolamine / pharmacology*
Grant Support
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Receptors, Muscarinic; 51-34-3/Scopolamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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