Document Detail


Concurrent muscarinic and beta-adrenergic blockade in rats impairs place-learning in a water maze and retention of inhibitory avoidance.
MedLine Citation:
PMID:  2161697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
These experiments examined the effects of separate and concurrent muscarinic cholinergic and beta-adrenergic blockade on inhibitory (passive) avoidance performance and spatial learning in the Morris water maze. Pretraining systemic administration of either scopolamine (0.3 or 1.0 mg/kg) or propranolol (3.0 or 10.0 mg/kg) had no significant effect on one-day retention of step-through inhibitory avoidance training. Similarly, pretraining administration of either 0.3 mg/kg scopolamine or 10 mg/kg propranolol did not affect spatial learning in the Morris water maze. However, combined administration of scopolamine and 10.0 mg/kg of propranolol impaired performance on these tasks. These findings further support a role for interactions between norepinephrine and acetylcholine in the modulation of learning and memory and implicate the participation of beta-adrenergic mechanisms in this interaction. Because cholinergic and noradrenergic deterioration is found in aging and Alzheimer's disease, these results also have implications regarding the role of age-related noradrenergic and cholinergic dysfunction in cognitive decline.
Authors:
M W Decker; T M Gill; J L McGaugh
Related Documents :
22622097 - Radiation dose to surgeons in theatre.
8981577 - Evaluation of perinatal flumazenil effects on the behavior of female rla/verh rats in a...
8619007 - A comparative study of the psychological effects of dn-2327, a partial benzodiazepine a...
1913177 - Pharmacological consequences of cholinergic plus serotonergic manipulations.
8052507 - Monitoring the efficacy of different doses of praziquantel by quantification of circula...
2870177 - Cardiovascular responses to the stimulation of alpha-1 and alpha-2 adrenoceptors in the...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  513     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-17     Completed Date:  1990-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Affiliation:
Department of Psychobiology, University of California, Irvine 92717.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects*
Male
Memory / drug effects*
Propranolol / pharmacology*
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta / drug effects,  physiology*
Receptors, Muscarinic / drug effects,  physiology*
Scopolamine / pharmacology*
Grant Support
ID/Acronym/Agency:
AG055446/AG/NIA NIH HHS; MH12526/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Receptors, Muscarinic; 51-34-3/Scopolamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Opioids act at mu-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium co...
Next Document:  Effects of corticotropin-releasing factor (CRF) and opiates on amphibian locomotion.