Document Detail


Concurrent bacterial infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease.
MedLine Citation:
PMID:  15803295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify demographic, clinical, and laboratory variables predictive for a concurrent bacterial pulmonary infection in ventilated infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) and investigate antimicrobial drug use. DESIGN AND SETTING: Retrospective, observational study in a 14-bed pediatric intensive care unit. PATIENTS: 82 infants younger than 1 year of age with a virologically confirmed RSV LRTD during 1996-2001, of whom 65 were mechanically ventilated. RESULTS: Microbiological data were available from 38 ventilated infants, 10 of whom had a positive blood culture (n=1) or endotracheal aspirate (n=9) obtained upon admission to the pediatric intensive care unit (PICU). Infants with a positive culture had a lower mean gestational age but were otherwise demographically comparable to those with negative culture results. Infants with a positive culture were ventilated 4 days longer. Indicators for a concurrent bacterial infection were comparable between ventilated and nonventilated infants. Antimicrobial drugs were used in 95.1% of infants (100% of ventilated infants) with a mean duration of 7.8+/-0.3 days. The moment of initiation and duration of antimicrobial drug treatment varied considerably. CONCLUSIONS: We observed in ventilated infants a low occurrence of concurrent bacterial pulmonary infection, but infants with positive cultures needed prolonged ventilatory support. Improvement in the diagnosis of a pulmonary bacterial infection is warranted to reduce the overuse of antimicrobial drugs among ventilated infants with RSV LRTD and to restrict these drugs to the proper patients.
Authors:
Martin C J Kneyber; Heleen Blussé van Oud-Alblas; Margreet van Vliet; Cuno S P M Uiterwaal; Jan L L Kimpen; Adrianus J van Vught
Related Documents :
23013325 - Fetal alcohol-related growth restriction from birth through young adulthood and moderat...
8726155 - Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebuli...
23273865 - Feeding and drinking skills in preterm and low birth weight infants compared to full te...
16397875 - Effects of pressure support ventilation plus volume guarantee vs. high-frequency oscill...
17667715 - Disaccharidase activity in infants and comparison based on symptoms and histological ch...
24436365 - Cholestasis and meconium ileus in infants with cystic fibrosis and their clinical outco...
Publication Detail:
Type:  Journal Article     Date:  2005-04-01
Journal Detail:
Title:  Intensive care medicine     Volume:  31     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2006-01-27     Revised Date:  2006-03-16    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-5     Citation Subset:  IM    
Affiliation:
Department of Pediatric Intensive Care, VU University Medical Center, P.O. Box 7507, 1007 MB Amsterdam, The Netherlands. m.kneyber@vumc.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use
Bacteremia / epidemiology
Bacterial Infections / epidemiology*
Comorbidity
Female
Humans
Infant
Infant, Newborn
Logistic Models
Male
Multivariate Analysis
Netherlands / epidemiology
Respiration, Artificial*
Respiratory Syncytial Virus Infections / epidemiology*,  therapy
Respiratory Tract Infections / epidemiology*,  etiology,  therapy
Retrospective Studies
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and veno...
Next Document:  The involvement of intensive care nurses in end-of-life decisions: a nationwide survey.