| Concurrent administration of rhesus rotavirus tetravalent (RRV-TV) vaccine with pentavalent diphtheria-pertussis-tetanus-Haemophilus influenzae beta-inactivated polio and hepatitis B vaccines. | |
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MedLine Citation:
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PMID: 10426173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the incorporation of oral rhesus-human reassortant rotavirus tetravalent (RRV-TV) vaccine into a routine immunization programme, RRV-TV or oral placebo was coadministered with a pentavalent diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae b (Hib)-inactivated polio vaccine and hepatitis B vaccine following a 3-4-5-mo schedule in a double-blind trial involving 249 infants. Seroconversion rates after 3 doses of rotavirus vaccine were 80% for rotavirus immunoglobulin A (IgA) and 93% for RRV neutralizing antibodies. Rotavirus vaccine did not interfere with the immune responses to diphtheria, tetanus, pertussis, Hib, poliovirus 1, 2 and 3, or hepatitis B. Following the first, second and third doses of vaccine, fever >38 degrees C on the day of vaccination was seen in 31%, 24% and 24%, respectively, with no difference between RRV-TV- and placebo-vaccinated children. This fever was presumably due to the whole-cell pertussis vaccine. Those vaccinees who received concomitant RRV-TV vaccine had another peak of fever around d 4 after the first dose, when 25% of them had fever >38 degrees C and 3% >39 degrees C. It is concluded that RRV-TV rotavirus vaccine can be given concurrently with other childhood immunizations following a 3-4-5-mo vaccination schedule. However, febrile reactions to RRV-TV rotavirus vaccine are common when the first dose is given at the age of 3 mo. |
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Authors:
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T Vesikari; J Joensuu; M Baer; H Käyhty; R M Olander; H Sormunen; A Miettinen; R L Ward; T Guillot |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 88 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 513-20 Citation Subset: IM |
Affiliation:
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University of Tampere Medical School, Finland. lltive@uta.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Formation
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immunology Child, Preschool Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage, immunology* Double-Blind Method Haemophilus Vaccines / administration & dosage, immunology* Haemophilus influenzae type b / immunology* Hepatitis B Vaccines / administration & dosage, immunology* Humans Immunization Schedule Immunoglobulin G / immunology Infant Poliovirus Vaccine, Inactivated / administration & dosage, immunology* Time Factors Vaccines, Attenuated / administration & dosage, immunology Vaccines, Combined / administration & dosage, immunology Vaccines, Conjugate / administration & dosage, immunology Vaccines, Inactivated / administration & dosage, immunology Viral Vaccines / administration & dosage, immunology |
| Chemical | |
Reg. No./Substance:
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0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Haemophilus Vaccines; 0/Hepatitis B Vaccines; 0/Immunoglobulin G; 0/Poliovirus Vaccine, Inactivated; 0/Vaccines, Attenuated; 0/Vaccines, Combined; 0/Vaccines, Conjugate; 0/Vaccines, Inactivated; 0/Viral Vaccines |
| Comments/Corrections | |
Comment In:
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Acta Paediatr. 1999 Aug;88(8):800-2
[PMID:
10503675
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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