| Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. | |
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MedLine Citation:
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PMID: 20464643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraocular lymphoma (IOL) is rare lymphoma that frequently infiltrates the central nervous system (CNS). An optimal treatment has not been established, and its prognosis is quite poor. We treated three IOL patients with CNS involvement by concurrent administration of intravenous and intravitreal methotrexate (MTX) injection. The intraocular lesion responded in all patients. One patient achieved complete response (CR), whereas the other 2 patients were in partial response for CNS lesion, added whole brain radiation and achieved CR. In 3 eyes of 2 patients, an intravitreal MTX injection (vMTX) was administered 2 h after a systemic MTX injection (sMTX) and the intravitreal MTX concentration was measured twice: 2 h after sMTX and 24 h after vMTX. The half-life of MTX in the vitreous fluid was estimated to be 12.4-21.5 h by assuming the first-order elimination kinetics. Although the concentration was still high 24 h after vMTX (69.94-82.89 muM), there were no ocular complications. The serum MTX concentration was not influenced by adding vMTX to sMTX. Grade 3 adverse event, leukocytopenia, was observed in only 1 patient. No grade 4 event was observed. Although further evaluation is required, concurrent sMTX and vMTX may be effective for IOL with CNS involvement. |
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Authors:
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Yusuke Nakauchi; Hiroshi Takase; Sunao Sugita; Manabu Mochizuki; Satoko Shibata; Yasuyoshi Ishiwata; Yuka Shibuya; Masato Yasuhara; Osamu Miura; Ayako Arai |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-13 |
Journal Detail:
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Title: International journal of hematology Volume: 92 ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 179-85 Citation Subset: IM |
Affiliation:
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Department of Hematology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antimetabolites, Antineoplastic Central Nervous System Neoplasms / drug therapy Drug Administration Routes Eye Neoplasms / drug therapy*, pathology Female Humans Lymphoma, Non-Hodgkin / drug therapy*, pathology Methotrexate / administration & dosage* Middle Aged Neoplasm Invasiveness Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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