Document Detail

Concurrent acute exercise alters central and peripheral responses to physostigmine.
MedLine Citation:
PMID:  8309962     Owner:  NLM     Status:  MEDLINE    
This study reports the modulatory effects of physostigmine (Phy) and concurrent acute exercise on the time course of cholinesterase (ChE) activity, the rate of decarbamylation (Kd), and half-time of recovery of ChE in red blood cells (RBC) and various tissues of rats. Acute exercise equivalent to 80% VO2-max (maximal oxygen consumption) transiently increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues. Physostigmine along with concurrent acute exercise increased the Kd in RBC, brain, and heart by 56.4%, 66.7%, and 139%, respectively, compared to Phy alone. The Kd in diaphragm and muscle decreased to 14.1% and 56.2%, respectively, compared to Phy alone. The variation in Kd might be due to the effect of concurrent acute exercise on the redistribution of Phy in various tissues of rat as a result of changes in blood flow.
S N Dube; S M Somani; S R Babu
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  46     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-15     Completed Date:  1994-03-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  827-34     Citation Subset:  IM; S    
Southern Illinois University, School of Medicine, Department of Pharmacology, Springfield 62794-9230.
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MeSH Terms
Brain / drug effects,  enzymology
Cholinesterases / blood*
Erythrocytes / drug effects,  enzymology
Muscles / drug effects,  enzymology
Myocardium / enzymology
Oxygen Consumption / drug effects
Physical Exertion / physiology*
Physostigmine / pharmacokinetics,  pharmacology*
Rats, Sprague-Dawley
Respiratory Muscles / drug effects,  enzymology
Reg. No./Substance:
57-47-6/Physostigmine; EC

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