| Concurrent acute exercise alters central and peripheral responses to physostigmine. | |
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MedLine Citation:
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PMID: 8309962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study reports the modulatory effects of physostigmine (Phy) and concurrent acute exercise on the time course of cholinesterase (ChE) activity, the rate of decarbamylation (Kd), and half-time of recovery of ChE in red blood cells (RBC) and various tissues of rats. Acute exercise equivalent to 80% VO2-max (maximal oxygen consumption) transiently increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues. Physostigmine along with concurrent acute exercise increased the Kd in RBC, brain, and heart by 56.4%, 66.7%, and 139%, respectively, compared to Phy alone. The Kd in diaphragm and muscle decreased to 14.1% and 56.2%, respectively, compared to Phy alone. The variation in Kd might be due to the effect of concurrent acute exercise on the redistribution of Phy in various tissues of rat as a result of changes in blood flow. |
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Authors:
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S N Dube; S M Somani; S R Babu |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 46 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-15 Completed Date: 1994-03-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 827-34 Citation Subset: IM; S |
Affiliation:
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Southern Illinois University, School of Medicine, Department of Pharmacology, Springfield 62794-9230. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, enzymology Cholinesterases / blood* Erythrocytes / drug effects, enzymology Male Muscles / drug effects, enzymology Myocardium / enzymology Oxygen Consumption / drug effects Physical Exertion / physiology* Physostigmine / pharmacokinetics, pharmacology* Rats Rats, Sprague-Dawley Respiratory Muscles / drug effects, enzymology |
| Chemical | |
Reg. No./Substance:
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57-47-6/Physostigmine; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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