Document Detail


Concurrent access to two concentrations of orally delivered phencyclidine: effects of feeding conditions.
MedLine Citation:
PMID:  3612021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two experiments addressed the effects of food satiation and deprivation on oral self-administration of two concurrently available phencyclidine concentrations. In the first experiment, 8 rhesus monkeys self-administered either of two concentrations of phencyclidine ("PCP, angel dust") and water under concurrent fixed-ratio 16 schedules. One concentration was always held constant (0.25 mg/mL) while a series of other phencyclidine concentrations, ranging from 0 (water) to 1.0 mg/mL, was presented in a nonsystematic order. Initially the monkeys were tested while food satiated, and the procedure was then repeated during food deprivation. The monkeys usually selected the higher concentration within the first few minutes of the session, indicating that taste and/or other immediate postingestional effects were important factors. Contrary to a number of previous reports, there were no consistent differences across subjects in the mean number of liquid deliveries or mean drug intake (mg/kg) during food satiation and deprivation. However, for all monkeys the within-session time course of responding during food satiation consistently differed from that during deprivation. A second experiment assessed whether the failure to find consistent differences in drug intake during food satiation and deprivation had been due to the history of concurrent access to different phencyclidine concentrations or to the extended experience with phencyclidine under food-satiation conditions. Six additional monkeys (Group 2) were exposed to the phencyclidine self-administration procedure (during food satiation and deprivation) for the same length of time as the monkeys in Experiment 1 (Group 1), except they received only concurrent access to phencyclidine (0.25 mg/mL) and water. Both groups then received concurrent access to phencyclidine and water during five repeated cycles of food deprivation and satiation. There were also marked individual differences in Group 2: During food satiation, 2 of the monkeys' responding increased, 1 showed no change, and 3 decreased. Examination of a number of historical variables indicated that the greater the percentage of total sessions spent during food satiation with phencyclidine available (before these experiments began), the greater the amounts of phencyclidine consumed during food satiation and the smaller the differences in phencyclidine intake when the two feeding conditions were compared.
Authors:
M E Carroll
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  47     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Food Deprivation*
Macaca mulatta
Male
Phencyclidine / administration & dosage*
Reinforcement Schedule
Satiation*
Self Administration
Grant Support
ID/Acronym/Agency:
DA 02486/DA/NIDA NIH HHS; DA 03240/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
77-10-1/Phencyclidine
Comments/Corrections

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