Document Detail

Concurrent access to sucrose pellets decreases methamphetamine-seeking behavior in Lewis rats.
MedLine Citation:
PMID:  18495228     Owner:  NLM     Status:  MEDLINE    
Investigation of the role of choice between use of drugs of abuse and pursuit of alternative non-drug reinforcers is receiving greater attention. An understanding of the determinants influencing choice between drugs and alternative reinforcers will eventually lead to an understanding to the neural substrates of the drug altered brain. We investigated the impact of concurrent access to sucrose pellets on methamphetamine self-administration and self-regulated reinstatement of methamphetamine seeking following extinction training in Lewis rats. Our results from the self-administration experiment show that rats with concurrent access to sucrose self-administered significantly less methamphetamine compared to the methamphetamine only group. For our extinction/reinstatement experiment, concurrent access to sucrose during self-regulated methamphetamine reinstatement reduced methamphetamine intake and non-reinforced methamphetamine-seeking behavior in rats compared to rats that received access to just methamphetamine. These findings indicate that concurrent access to alternative reinforcers during various stages of methamphetamine-seeking behavior robustly decreased methamphetamine intake and serves as a valid rodent choice paradigm.
Ansong Ping; Paul J Kruzich
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Publication Detail:
Type:  Journal Article     Date:  2008-04-16
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  90     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  IM    
Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912-3000, United States.
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MeSH Terms
Amphetamine-Related Disorders / psychology*
Central Nervous System Stimulants / pharmacology*
Conditioning, Operant / drug effects
Dose-Response Relationship, Drug
Extinction, Psychological / drug effects
Methamphetamine / pharmacology*
Rats, Inbred Lew
Reinforcement (Psychology)
Sucrose / pharmacology*
Survival Analysis
Reg. No./Substance:
0/Central Nervous System Stimulants; 537-46-2/Methamphetamine; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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