| Concurrent MR blood volume and vessel size estimation in tumors by robust and simultaneous ΔR(2) and ΔR(2) * quantification. | |
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MedLine Citation:
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PMID: 21305604 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This work presents a novel method for concurrent estimation of the fractional blood volume and the mean vessel size of tumors based on a multi-gradient-echo-multi-spin-echo sequence and the injection of a super-paramagnetic blood-pool agent. The approach further comprises a post-processing technique for simultaneous estimation of changes in the transverse relaxation rates R(2) and R 2*, which is robust against global B(0) and B(1) field inhomogeneities and slice imperfections. The accuracy of the simultaneous ΔR(2) and ΔR 2* quantification approach is evaluated in a phantom. The simultaneous blood volume and vessel size estimates, obtained with MR, compare well to the immunohistological findings in a preclinical experiment (HT1080 cells, implanted in nude mice). Clinical translation is achieved in a patient with a pleomorphic sarcoma in the left pubic bone. The latter demonstrates the robustness of the technique against changes in the contrast agent concentration in blood during washout. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Stefanie Remmele; Janine Ring; Julien Sénégas; Walter Heindel; Rolf M Mesters; Christoph Bremer; Thorsten Persigehl |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Philips Research, Hamburg, Germany. Stefanie.Remmele@philips.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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