Document Detail

Concurrence of angiographic coronary artery disease in patients with apical ballooning syndrome (tako-tsubo cardiomyopathy).
MedLine Citation:
PMID:  18798323     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the coexistence of coronary artery disease (CAD) in an unselected cohort of patients with apical ballooning syndrome (ABS).
BACKGROUND: ABS is a clinical condition of unknown etiology with symptoms that mimic an acute coronary syndrome and is characterized by the presence of transient left ventricular dysfunction primarily affecting the apex of the heart.
METHODS: We conducted a retrospective case series in a single tertiary care hospital. Patients were identified by searching for several inclusive discharge diagnoses in all hospitalized patients. Suspected cases were analyzed using prespecified diagnostic criteria. Demographic, clinical, and imaging data were collected. Coronary lesions were assessed by quantitative angiography.
RESULTS: Thirty-one cases of ABS were identified. The majority of the cases were female, and ischemia was documented in all patients by electrocardiographic or cardiac biomarker criteria. Nineteen patients (61.3%) had angiographic evidence of CAD, with multivessel involvement in seven (23%). Nine patients (29%) had luminal stenosis severity greater than 50% in at least one epicardial vessel.
CONCLUSIONS: In an unselected cohort of patients with ABS, coronary atherosclerosis is commonly present. Whether CAD simply coexists or is related to the pathophysiology of ABS is unclear.
David E Winchester; Michael Ragosta; Angela M Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  72     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-01-23     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-6     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
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MeSH Terms
Aged, 80 and over
Angina Pectoris / etiology,  radiography
Biological Markers / blood
Coronary Angiography*
Coronary Artery Disease / complications*,  physiopathology,  radiography*
Middle Aged
Myocardial Ischemia / etiology,  radiography
Retrospective Studies
Takotsubo Cardiomyopathy / complications*,  physiopathology,  radiography*
Troponin / blood
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Troponin
Comment In:
Catheter Cardiovasc Interv. 2008 Nov 1;72(5):617   [PMID:  18949775 ]
Catheter Cardiovasc Interv. 2008 Nov 1;72(5):618   [PMID:  18949776 ]
Catheter Cardiovasc Interv. 2009 Apr 1;73(5):717   [PMID:  19198008 ]

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