| Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births. | |
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MedLine Citation:
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PMID: 11853715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The concordance of strabismic phenotypes was examined in monozygotic versus multizygotic twins and other multiple births to study the role of genetic background in different types of commitant strabismus. METHODS: Medical charts of 45 consecutive pairs of twins (16 monozygotic and 18 dizygotic twins, and 11 with unknown zygosity), 3 sets of triplets (one monozygotic and 2 trizygotic triplets), and one set of quadruzygotic quadruplets examined at 6 institutions between 1973 and 1999 were reviewed retrospectively. The concordance was defined as both or all members having either esotropia or exotropia in common. RESULTS: The concordance of strabismic phenotypes was noted in 33 of 49 pairs or sets (67.3%): 14 of 17 monozygotic twins or triplets (82.4%), 10 of 21 multizygotic twins, triplets, or quadruplets (47.6%), and 9 of 11 twins with unknown zygosity (81.8%). The concordance rate was significantly higher in monozygosity than in multizygosity (P =.043, Fisher exact probability test). The predominant concordant phenotypes in monozygosity were accommodative esotropia and intermittent exotropia. CONCLUSION: A high concordance rate of strabismic phenotypes, predominantly of accommodative esotropia and intermittent exotropia in monozygosity, suggests the genetic background for these types of strabismus. |
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Authors:
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Toshihiko Matsuo; Mizue Hayashi; Hirotake Fujiwara; Takashi Yamane; Hiroshi Ohtsuki |
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Publication Detail:
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Type: Journal Article; Twin Study |
Journal Detail:
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Title: Japanese journal of ophthalmology Volume: 46 ISSN: 0021-5155 ISO Abbreviation: Jpn. J. Ophthalmol. Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-02-20 Completed Date: 2002-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diseases in Twins
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genetics* Female Humans Male Multiple Birth Offspring / genetics Phenotype Quadruplets / genetics* Retrospective Studies Strabismus / genetics* Triplets / genetics* Twins, Dizygotic / genetics* Twins, Monozygotic / genetics* |
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