| Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins. | |
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MedLine Citation:
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PMID: 18727671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the changes in the multiple sclerosis (MS) concordance in twins, and the contribution of genetic and environmental factors to the aetiology of MS in Finland. BACKGROUND: Both genes and the environment contribute to the development of MS. A well-conducted twin study is an excellent means to assess the relative contribution of heritability and environmental factors. METHODS: Multiple sclerosis concordance was assessed for 10 Monozygotic and 14 dizygotic twin pairs using pairwise and probandwise concordance rates. The tetrachoric correlations in liability to disease for twin pairs were computed and a polygenic multifactorial model was used to estimate heritability. RESULTS: The pairwise concordance for MZ twins was 30% and for the DZ twins 14.3%, compared with 30% for MZ and 0% for DZ 20 years ago. The corresponding probandwise concordance rates were 46.2% and 25%. The genetic variance (heritability) was 15.3% (95% Cl 0.0-77.6), the common environmental variance 73.7% (95% Cl 14.1-93.9) and the unique environmental variance 11.1% (95% Cl 2.3-30.0). CONCLUSIONS: As the concordance of MS in DZ twins has increased during the past two decades and the heritability estimate is low, it seems that the reported increase in MS incidence in Finland is mainly caused by environmental factors. |
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Authors:
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H Kuusisto; J Kaprio; E Kinnunen; T Luukkaala; M Koskenvuo; I Elovaara |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2008-08-25 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 15 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1106-10 Citation Subset: IM |
Affiliation:
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Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland. hanna.kuusisto@pshp.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cohort Studies Diseases in Twins / epidemiology*, genetics Environment Female Finland / epidemiology Genetic Predisposition to Disease Humans Incidence Male Middle Aged Models, Genetic Multiple Sclerosis / epidemiology, genetics* Twins, Dizygotic Twins, Monozygotic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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