| Concord grape juice supplementation and neurocognitive function in human aging. | |
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MedLine Citation:
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PMID: 22468945 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated with health benefits including improvement in cognition and neuronal function with aging. Concord grape juice contains polyphenols, including anthocyanins and flavanols, and previous research has shown improvement in a number of human health conditions with grape juice supplementation. In the current study, older adult subjects with Mild Cognitive Impairment consumed Concord grape juice or placebo for 16-weeks and were administered assessments of memory function and brain activation pre- and post-intervention. Participants who consumed grape juice showed reduced semantic interference on memory tasks. We also observed relatively greater activation in anterior and posterior regions of the right hemisphere with functional magnetic resonance imaging in the grape juice treated subjects. These findings provide further evidence that Concord grape juice can enhance neurocognitive function in older adults with mild memory decline. KEYWORDS: Concord grape juice; memory; Mild Cognitive Impairment; brain activation; aging. |
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Authors:
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Robert Krikorian; Erin L Boespflug; David E Fleck; Amanda L Stein; Jolynne D Wightman; Marcelle D Shidler; Sara Sadat-Hossieny |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-2 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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