| Concomitant use of gastric acid-reducing agents is frequent among HIV-1-infected patients receiving protease inhibitor-based highly active antiretroviral therapy. | |
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MedLine Citation:
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PMID: 17461849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to assess the frequency of the concurrent use of gastric acid-reducing agents among HIV-1-infected patients treated with highly active antiretroviral therapy (HAART) combinations. METHODS: An anonymous, semistructured, self-administered questionnaire was consecutively distributed among HIV-1-infected patients at routine visits to specialized HIV clinics. The questionnaire contained 17 items asking specifically for information on current antiretroviral treatments and the use of gastric acid-reducing agents as well as demographic data. RESULTS: A total of 424 patients in 12 centres participated in the study: 85% were male, 88% were of German nationality, 82% were >35 years of age and 201 (47.4%) were receiving a protease inhibitor (PI)-containing HAART regimen. Of these, 74 (37%) had received an acid-reducing drug within the previous 6 months and 43 (58%) were currently still on it. Two-thirds of patients (64.9%) were treated with proton-pump inhibitors (pantoprazole, omeprazole or esomeprazole) and 56% of patients on PI-containing regimens had been taking these drugs for longer than 2 months and up to a maximum of 3 years. The majority of patients (77%) had received the prescription for the acid-reducing drugs from their HIV specialist and the remaining patients had received over the counter (OTC) medication or prescriptions from other medical personnel. CONCLUSIONS: A substantial subset of patients treated with HAART combinations, including those on PI-containing regimens, were using concomitant acid-reducing drugs, most often proton-pump inhibitors. As negative drug-drug interactions between some of the (boosted) PIs and gastric acid-reducing agents have recently been reported, HIV physicians should take this into account when prescribing PI-containing HAART combinations in order to avoid an additional risk of treatment failure. |
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Authors:
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J van Lunzen; H Liess; K Arastéh; R Walli; B Daut; D Schürmann |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: HIV medicine Volume: 8 ISSN: 1464-2662 ISO Abbreviation: HIV Med. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-27 Completed Date: 2007-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897392 Medline TA: HIV Med Country: England |
Other Details:
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Languages: eng Pagination: 220-5 Citation Subset: IM |
Affiliation:
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University Medical Center Hamburg--Eppendorf, Infectious Diseases Unit, Hamburg, Germany. v.lunzen@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antacids / therapeutic use* Antiretroviral Therapy, Highly Active / methods* Drug Interactions Female HIV Infections / drug therapy* HIV Protease Inhibitors / therapeutic use* HIV-1 / growth & development* Humans Male Middle Aged Proton Pump Inhibitors / therapeutic use* Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/HIV Protease Inhibitors; 0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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