| Concomitant rheumatoid arthritis and amyotrophic lateral sclerosis: report of two new cases and review of literature. | |
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MedLine Citation:
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PMID: 21258799 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To describe a rare association between rheumatoid arthritis (RA) and amyotrophic lateral sclerosis (ALS). Two new cases of patients with RA who developed amyotrophic lateral sclerosis (ALS), one receiving anti-TNFα agents, were reported. Only other five cases of this rare association have been previously described in literature. The simultaneous presence of the two diseases represents a difficult diagnostic challenge because RA may mimic some musculoskeletal symptoms of ALS. There is no evidence in favor of a common pathophysiologic mechanism, and thus the possibility of a fortuitous association must be raised. A neurotoxic side effect of various drugs for RA treatment could be considered. Casual or causal association remains a difficult choice. The possibility of a coincidental association must be raised but neurologic side effects of TNFα blockers lead to discussion. |
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Authors:
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Melissa Padovan; Luisa Maria Caniatti; Francesco Trotta; Marcello Govoni |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-22 |
Journal Detail:
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Title: Rheumatology international Volume: - ISSN: 1437-160X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Rheumatology Unit, Department of clinical and experimental medicine, University of Ferrara and Azienda Ospedaliero-Universitaria Sant'Anna Hospital of Ferrara, Corso Giovecca, 203-44100, Ferrara, Italy, melipadovan@yahoo.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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