Document Detail

Concomitant primary polycythemia vera and follicle center cell non-Hodgkin lymphoma: a case report and review of the literature.
MedLine Citation:
PMID:  12533050     Owner:  NLM     Status:  MEDLINE    
The association of myeloproliferative and lymphoproliferative disorders is well known after cytotoxic drug or radiation exposure, while it is remarkably rare prior to therapy. We report on a patient simultaneously diagnosed as having polycythemia vera and II3A follicle center cell non-Hodgkin lymphoma (grade 1). At this timepoint, he is on 12-year follow-up, characterized by post-polycythemia myeloid metaplasia with myelofibrosis and persistent complete remission of lymphoma. The conventional marrow cytogenetic analysis performed during the course of the disease demonstrated an abnormal karyotype with deletion of the long arm of chromosome 20 and trisomy 8, while molecular analysis failed to detect BCR-ABL rearrangement in peripheral blood cells. To the best of our knowledge based on a computer-aided review of the literature (MED-LINE 1966-2002), this is the sixth case of concomitant primary polycythemia vera and lymphoma of non-Hodgkin type. Besides, there is a single literature report on polycythemia vera coexisting with the Hodgkin's lymphoma. In our case as well as in the recorded ones, two independent malignant clones of myeloid and lymphoid origin, respectively, seem to have arisen. Further reports, supported by chromosomal and molecular studies, could improve our knowledge on this extremely infrequent disease association.
Rita Rizzi; Arcangelo Liso; Alessandra Pannunzio; Paola Carluccio; Giorgina Specchia; Vincenzo Liso
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  43     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-20     Completed Date:  2003-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  2217-20     Citation Subset:  IM    
Hematology Section, Internal Medicine and Public Medicine Department, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11-70124 Bari, Italy.
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MeSH Terms
Antineoplastic Agents / therapeutic use
Clone Cells / pathology
Lymphoma, Follicular / diagnosis,  pathology*
Neoplasms, Second Primary / pathology
Polycythemia Vera / diagnosis,  pathology*
Remission Induction
Reg. No./Substance:
0/Antineoplastic Agents

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