Document Detail

Concomitant papillary thyroid carcinoma and Hashimoto's thyroiditis.
MedLine Citation:
PMID:  11403259     Owner:  NLM     Status:  MEDLINE    
An association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) is well recognized. Both entities may often display overlapping morphologic features. The aim of this study was to evaluate the accuracy of fine needle aspiration (FNA) of concomitant PTC and HT. Twenty nine thyroid FNAs with a diagnosis of concomitant PTC and HT on follow-up surgical material were retrospectively reviewed (11% of all HT cases diagnosed in the same period of time). The cytologic specimens were evaluated for the presence of diagnostic features of PTC and HT. In 16 of 29 cases, the diagnosis of PTC was made or suggested; however, only in 3 cases were both entities recognized on the FNA material. The review of the remaining cases (13 cases) showed diagnostic features of PTC in 2 cases (interpretation errors), some features of PTC in 8 cases (insufficient diagnostic features), features of only HT in 2 cases, and 1 case was acellular (sampling errors). Originally, 10 cases with features of PTC were diagnosed as either follicular neoplasm or colloid nodule with or without HT. Histologically, 1 of 13 cases was a cystic variant and 7 of 13 cases were follicular variants of papillary carcinoma. It is important to be aware of the coexistence of PTC and HT. Deliberate search for evidences of PTC in every case of HT may be necessary to improve diagnostic accuracy of the FNA. However, the cytologic diagnosis of follicular variant of PTC coexisting with HT can be challenging. The sampling error may also cause false negative results.
L H Liu; R Bakhos; E M Wojcik
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Seminars in diagnostic pathology     Volume:  18     ISSN:  0740-2570     ISO Abbreviation:  Semin Diagn Pathol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-12-07     Revised Date:  2007-05-16    
Medline Journal Info:
Nlm Unique ID:  8502262     Medline TA:  Semin Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA.
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MeSH Terms
Biopsy, Needle* / methods
Carcinoma, Papillary / complications,  diagnosis*,  pathology
Diagnostic Errors
False Negative Reactions
Middle Aged
Retrospective Studies
Selection Bias
Thyroid Diseases / complications,  diagnosis*,  pathology
Thyroid Neoplasms / complications,  diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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