Document Detail


Concomitant increase by peroxisome proliferators of fatty acid-binding protein, peroxisomal beta-oxidation and cytosolic acyl-CoA hydrolase in liver.
MedLine Citation:
PMID:  2865776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inductions of FABP in hepatic cytosol by administration of tiadenol and clofibric acid were studied in rats, mice and guinea-pigs. In rats and mice, [1-14C]oleic acid-binding capacity of hepatic cytosol was increased, in association with induction of peroxisomal beta-oxidation, by the administration of either the two peroxisome proliferators. The increase in [1-14C]oleic acid binding capacity was responsible for the increase in the content of FABP in livers. The peroxisome proliferators caused an induction of acyl-CoA hydrolase of lower-molecular-weight form alone in hepatic cytosol of mice, although inductions of two long-chain acyl-CoA hydrolases (higher- and lower-molecular-weight form) were brought about in hepatic cytosol of rats. Guinea-pigs lacked the peroxisome proliferator-caused inductions of FABP, peroxisomal beta-oxidation and acyl-CoA hydrolase. There was no essential difference in the inductions of FABP, acyl-CoA hydrolases and peroxisomal beta-oxidation between tiadenol and clofibric acid, despite a marked difference in their chemical structures. These results suggest that the induction of FABP is correlated with the inductions of both peroxisomal beta-oxidation and cytosolic long-chain acyl-CoA hydrolase of lower-molecular-weight form.
Authors:
H Katoh; Y Kawashima; M Takegishi; H Watanuki; A Hirose; H Kozuka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  49     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-12-13     Completed Date:  1985-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / biosynthesis*
Cell Division / drug effects
Clofibrate / analogs & derivatives*
Clofibric Acid / pharmacology*
Cytosol / enzymology
Fatty Acid-Binding Proteins
Fatty Alcohols / pharmacology*
Guinea Pigs
Liver / metabolism*
Male
Mice
Mice, Inbred Strains
Microbodies / drug effects,  metabolism*
Molecular Weight
Neoplasm Proteins*
Nerve Tissue Proteins*
Oxidation-Reduction
Palmitoyl-CoA Hydrolase / biosynthesis*
Rats
Rats, Inbred Strains
Thiolester Hydrolases / biosynthesis*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Fabp5 protein, mouse; 0/Fabp7 protein, mouse; 0/Fabp7 protein, rat; 0/Fatty Acid-Binding Proteins; 0/Fatty Alcohols; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 637-07-0/Clofibrate; 6964-20-1/tiadenol; 882-09-7/Clofibric Acid; EC 3.1.2.-/Thiolester Hydrolases; EC 3.1.2.2/Palmitoyl-CoA Hydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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