Document Detail

Concomitant clozapine reduces smoking in patients treated with risperidone.
MedLine Citation:
PMID:  11788244     Owner:  NLM     Status:  MEDLINE    
This pilot study examines the smoking behaviors of patients treated with either risperidone alone or in combination with clozapine. Smoking behavior was evaluated using expired carbon monoxide (CO) measurements, the Fagerstrom Test for Nicotine Dependence (FTND), and a semi-structured interview. Our results indicate that patients co-prescribed clozapine with risperidone smoke significantly less than patients treated with risperidone alone (19.1+/-9.3 vs. 37.8+/-19.1 ppm CO, respectively, P=0.03). These data are consistent with previous studies showing that clozapine treatment is associated with significantly reduced smoking behavior relative to other antipsychotic agents.
Ric M Procyshyn; Gordon Tse; Osric Sin; Sean Flynn
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  12     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-14     Completed Date:  2002-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Division of Medical Services, Riverview Hospital, Port Coquitlam, BC, Canada.
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Clozapine / therapeutic use*
Cross-Sectional Studies
Drug Therapy, Combination
Middle Aged
Pilot Projects
Risperidone / therapeutic use*
Schizophrenia / drug therapy
Smoking / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 106266-06-2/Risperidone; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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