Document Detail

Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension.
MedLine Citation:
PMID:  18404602     Owner:  NLM     Status:  MEDLINE    
Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II antagonists (ARBs)] are widely used today to initiate antihypertensive treatment but, when given as monotherapy, do not suffice in most patients to normalise blood pressure (BP). Combining a CA and either an ACE-inhibitor or an ARB considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. Several fixed-dose combinations are available (CA + ACE-inhibitors: amlodipine + benazepril, felodipine + ramipril, verapamil + trandolapril; CA + ARB: amlodipine + valsartan). They are expected not only to improve BP control, but also to facilitate long-term adherence with antihypertensive therapy, thereby providing maximal protection against the cardiovascular and renal damage caused by high BP.
Boris Gojanovic; François Feihl; Lucas Liaudet; Bernard Waeber
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  9     ISSN:  1470-3203     ISO Abbreviation:  J Renin Angiotensin Aldosterone Syst     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne, Switzerland.
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MeSH Terms
Angiotensin II / antagonists & inhibitors
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use
Atenolol / administration & dosage
Calcium Channel Blockers / adverse effects,  therapeutic use*
Drug Combinations
Drug Therapy, Combination
Enzyme Inhibitors / adverse effects,  therapeutic use
Hypertension / drug therapy*
Indoles / administration & dosage
Middle Aged
Randomized Controlled Trials as Topic
Renin-Angiotensin System / drug effects*
Sympathetic Nervous System / drug effects
Verapamil / administration & dosage
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Drug Combinations; 0/Enzyme Inhibitors; 0/Indoles; 11128-99-7/Angiotensin II; 29122-68-7/Atenolol; 52-53-9/Verapamil; 87679-37-6/trandolapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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