| Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension. | |
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MedLine Citation:
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PMID: 18404602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II antagonists (ARBs)] are widely used today to initiate antihypertensive treatment but, when given as monotherapy, do not suffice in most patients to normalise blood pressure (BP). Combining a CA and either an ACE-inhibitor or an ARB considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. Several fixed-dose combinations are available (CA + ACE-inhibitors: amlodipine + benazepril, felodipine + ramipril, verapamil + trandolapril; CA + ARB: amlodipine + valsartan). They are expected not only to improve BP control, but also to facilitate long-term adherence with antihypertensive therapy, thereby providing maximal protection against the cardiovascular and renal damage caused by high BP. |
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Authors:
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Boris Gojanovic; François Feihl; Lucas Liaudet; Bernard Waeber |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 9 ISSN: 1470-3203 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin II / antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors / adverse effects, therapeutic use Atenolol / administration & dosage Calcium Channel Blockers / adverse effects, therapeutic use* Drug Combinations Drug Therapy, Combination Enzyme Inhibitors / adverse effects, therapeutic use Humans Hypertension / drug therapy* Indoles / administration & dosage Middle Aged Randomized Controlled Trials as Topic Renin-Angiotensin System / drug effects* Sympathetic Nervous System / drug effects Verapamil / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Drug Combinations; 0/Enzyme Inhibitors; 0/Indoles; 11128-99-7/Angiotensin II; 29122-68-7/Atenolol; 52-53-9/Verapamil; 87679-37-6/trandolapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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