| Concomitant bone marrow metastasis of a glioblastoma multiforme revealed at the diagnosis. | |
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MedLine Citation:
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PMID: 16932995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rare occurrence of extra-neural metastases in patients having a tumour of the central nervous system (CNS) could mean that the symptoms of a metastatic lesion are confused with a second pathology. We recently treated a patient with a glioblastoma multiforme who was developing a pancytopaenia at the initial diagnosis. The frequent red cell and platelet transfusions were transitorily active. An extensive radiological investigation and a unilateral iliac bone marrow aspirate and biopsy were performed. Cells immunoreactive to glial fibrillary acidic protein were detected in a specimen obtained from the iliac bone. Post-mortem examination confirmed metastasis to extra-cranial bone and revealed other metastases in lung, mediastinal lymph node and spleen. Therefore, in patients with malignant glioma tumours, bone marrow metastasis, though not common, should be investigated when bone pain or cytopaenia occur. |
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Authors:
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A Didelot; L Taillandier; Y Grignon; H Vespignani; P Beauchesne |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-08-25 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 148 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-05 Completed Date: 2007-05-02 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 997-1000 Citation Subset: IM |
Affiliation:
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Neuro-Oncologie - Neurologie, CHU de Nancy, Hôpital Central, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Bone Marrow / pathology*, physiopathology Bone Marrow Neoplasms / diagnosis, secondary* Brain / pathology Brain Neoplasms / diagnosis, pathology* Fatal Outcome Glial Fibrillary Acidic Protein / analysis, metabolism Glioblastoma / diagnosis, secondary* Humans Lung Neoplasms / diagnosis, secondary* Male Pain, Intractable / drug therapy, etiology Pancytopenia / etiology, pathology, physiopathology Splenic Neoplasms / diagnosis, secondary* Tumor Markers, Biological / analysis, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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