Document Detail

Concomitant atherosclerotic disease detected by whole-body MR angiography in relation to coronary artery calcification in patients with coronary artery disease.
MedLine Citation:
PMID:  19941248     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Patients with coronary artery disease (CAD) show a high prevalence for concomitant atherosclerotic peripheral arterial disease (PAD). On the other hand, PAD seems to be an additional risk factor for cardiac events. We evaluated the correlation between arterial pathologies as found in whole-body MR angiography and coronary artery calcification (CAC) detected by electron beam computed tomography (EBCT) and multislice CT (MSCT). MATERIALS AND METHODS: Two hundred and twenty-eight patients (161 men; 67 women) with suspicion for CAD/known CAD underwent whole-body contrast-enhanced MR angiography (wb-ce-MRA) and EBCT/MSCT. An atherosclerosis index was calculated for each patient Index = (40)Sigma(n=1) w(i) with w(i) being the grading of the stenosis of the i (ten) of 40 arteria segments (grade: 0 - no plaque; 1 - plaque - < or = 50 % stenosis; 2 - > 50 % stenosis - < or = 90 % stenosis; 3 - > 90 % stenosis - < 100 % stenosis; 4 - occlusion). Correlations between CAC and atherosclerosis index were performed. RESULTS: Wb-ce MRA and CAC correlate only moderately in this population. An atherosclerosis index 8 renders a positive predictive value for a CAC 100 of 63.3 %. CONCLUSION: An atherosclerosis index as defined in this study does not fully correlate with the extent of CAD as revealed by catheter angiography or EBCT/MSCT, but it might theoretically mirror the increased risk by PAD. It thus might be a promising complementary parameter for the prediction of cardiac events. Future studies need to show its possible additional predictive impact.
K Seng; F Breuckmann; T Schlosser; J Barkhausen; K Geckeis; T Budde; C Hoefs; A Schmermund; R Erbel; S C Ladd
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-11-25
Journal Detail:
Title:  R?Fo : Fortschritte auf dem Gebiete der R?ntgenstrahlen und der Nuklearmedizin     Volume:  182     ISSN:  1438-9010     ISO Abbreviation:  Rofo     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507497     Medline TA:  Rofo     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  334-40     Citation Subset:  IM    
Copyright Information:
A A Georg Thieme Verlag KG Stuttgart A New York.
Universit?tsklinikum Essen, Abteilung f?r diagnostische und interventionelle Radiologie und Neuroradiologie.
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MeSH Terms
Calcinosis / diagnosis*
Coronary Angiography*
Coronary Artery Disease / diagnosis*
Heart Catheterization
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional*
Magnetic Resonance Angiography*
Middle Aged
Myocardial Infarction / diagnosis
Risk Assessment
Sensitivity and Specificity
Statistics as Topic
Tomography, Spiral Computed*
Whole Body Imaging*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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