Document Detail


Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes.
MedLine Citation:
PMID:  23355363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of advantages over previous cardiac models, however, questions of their immaturity complicate their adoption as a new in vitro model. hPS-CM differ from adult cardiomyocytes with respect to structure, proliferation, metabolism and electrophysiology, better approximating fetal cardiomyocytes. Time in culture appears to significantly impact phenotype, leading to what can be referred to as early and late hPS-CM. This work surveys the phenotype of hPS-CM, including structure, bioenergetics, sensitivity to damage, gene expression, and electrophysiology, including action potential, ion channels, and intracellular calcium stores, while contrasting fetal and adult CM with hPS-CM at early and late time points after onset of differentiation.
Authors:
Claire Robertson; David D Tran; Steven C George
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  31     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2014-05-02     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-37     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 AlphaMed Press.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / physiology
Humans
Myocytes, Cardiac / cytology*,  metabolism
Pluripotent Stem Cells / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
UH2 TR000481/TR/NCATS NIH HHS; UH2 TR000481/TR/NCATS NIH HHS
Comments/Corrections

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