Document Detail

Conceptualization of the liability for schizophrenia: clinical implications.
MedLine Citation:
PMID:  22034209     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Historically, the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for schizophrenia have emphasized several features, including symptoms of psychosis, a dissociation of symptoms from their etiology, a reliance on clinical symptoms, and a categorical approach to classifying the disorder. Although these emphases are quite useful, they have limitations. We review these here, and stress the importance of incorporating recent data on the genetic /biological and neurodevelopmental origins of schizophrenia into current conceptions of the disorder. We also review "schizotaxia, " which is a concept thai embodies this point of view, occurs before the onset of psychosis, and is hypothesized to represent the liability for schizophrenia. If our hypothesis on this point is correct, the identification of schizotaxic individuals will eventually facilitate the development of prevention strategies by identifying a premorbid (but clinically significant) condition for schizophrenia. Moreover, the identification of biological or neuropsychological components of schizotaxia will provide more specific bases for developing novel treatment interventions. Our initial attempts to develop protocols for the assessment and treatment of schizotaxia are encouraging, and will be reviewed.
M T Tsuang; W S Stone; S V Faraone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dialogues in clinical neuroscience     Volume:  1     ISSN:  1294-8322     ISO Abbreviation:  Dialogues Clin Neurosci     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2011-10-28     Completed Date:  2012-09-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101238198     Medline TA:  Dialogues Clin Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  153-64     Citation Subset:  -    
Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center and Brockton / West Roxbury Veterans Affairs Medical Center and Harvard Institute of Psychiatric Epidemiology and Genetics, USA; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
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