Document Detail

Conceptual frameworks and mouse models for studying sex differences in physiology and disease: Why compensation changes the game.
MedLine Citation:
PMID:  24509348     Owner:  NLM     Status:  Publisher    
A sophisticated mechanistic understanding of physiology and disease requires knowledge of how sex-biasing factors cause sex differences in phenotype. In therian mammals, all sex differences are downstream of the unequal effects of XX vs. XY sex chromosomes. Three major categories of sex-biasing factors are activational and organizational effects of gonadal hormones, and sex chromosome effects operating outside of the gonads. These three types of effects can be discriminated from each other with established experimental designs and animal models. Two important mouse models, which allow conclusions regarding the sex-biasing effects of sex chromosome complement, interacting with gonadal hormone effects, are the Four Core Genotypes model and the XY* model. Chromosome Y consomic strains give information about the role of the Y chromosome. An important recent change in sexual differentiation theory is the increasing realization that sex-biasing factors can counteract the effects of each other, reducing rather than producing sex differences in phenotype. This change in viewpoint rationalizes a change in experimental strategies for dissecting sex chromosome effects. The overall goal is to understand the sexome, defined as the sum of effects of sex-biasing factors on gene systems and networks.
Arthur P Arnold
Related Documents :
10593098 - Screening of ten plant species for metaphase chromosome preparation in adult mosquitoes...
76528 - Association of nucleolus organizer chromosomes in domestic sheep (ovis aries) shown by ...
2424278 - A simple method for staining of nucleoproteide equivalents in human fl cell chromosomes.
25197158 - Haplotype map of sickle cell anemia in tunisia.
16573528 - Genome-wide linkage disequilibrium in two japanese beef cattle breeds.
11029668 - Genetic mapping of two loci affecting ddt resistance in the malaria vector anopheles ga...
Publication Detail:
Type:  REVIEW     Date:  2014-2-6
Journal Detail:
Title:  Experimental neurology     Volume:  -     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Uncertainty of SWAT model at different DEM resolutions in a large mountainous watershed.
Next Document:  Expression and function of transcription factor cMyb during cranial neural crest development.