| Concepts and mechanisms of generalized central nervous system arousal. | |
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MedLine Citation:
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PMID: 18591465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A concept of generalized arousal of the CNS is presented and given an operational definition that leads to quantitative physical measures. Because this primitive arousal function underlies all motivated behavioral responses, cognitive functions, and emotional expression, disorders of generalized arousal can be associated with a large number of problems in medicine and public health, including vegetative states, attentional disorders, depression, occupational hazards, and problems with sleep and anesthesia. Some of its known mechanisms are briefly reviewed, at the levels of neuroanatomy, neurophysiology, and functional genomics. Generalized arousal contributes to the excitement and the activation of behaviors during specific arousal states. Data are summarized for four genomic/neurochemical systems through which changes in generalized arousal could affect sexual arousal, two of which heighten, and the other two of which reduce arousal. |
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Authors:
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Donald Pfaff; Ana Ribeiro; James Matthews; Lee-Ming Kow |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1129 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-01 Completed Date: 2008-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 11-25 Citation Subset: IM |
Affiliation:
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Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA. pfaff@rockefeller.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arousal / physiology* Behavior / physiology Central Nervous System / physiology* Humans Public Health Sexual Behavior / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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