Document Detail


Conception after iodine-131 therapy for differentiated thyroid cancer.
MedLine Citation:
PMID:  9848714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We reviewed the medical history of 26 women with differentiated thyroid cancer who became pregnant after receiving therapeutic doses of radioactive iodine (131I) in order to document the possibility of a greater risk for disorders in these pregnancies. There were a total of 39 pregnancies, 6 of which occurred during the first year after therapy. In 3 cases the following anomalies were encountered: a male suffering Trisomy 18 (Edward's syndrome), a female with constitutional aplastic anemia, and a male with a congenital hip dysplasia. Of the 33 pregnancies that occurred after the first year post-therapy, there were 2 spontaneous abortions and a male effected by ureteral stenosis. Based on these data, although it cannot be confirmed that these congenital disorders are due to the 131I therapy, we recommend that pregnancy be avoided for the first year after therapy.
Authors:
C Ayala; E Navarro; J R Rodríguez; H Silva; E Venegas; R Astorga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  8     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1009-11     Citation Subset:  IM    
Affiliation:
Servicio de Endocrinología y Nutrición, Hospial Universitario Virgen del Rocío, Sevilla, Spain.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Adult
Anemia, Aplastic / etiology
Chromosomes, Human, Pair 18
Constriction, Pathologic
Female
Fertilization* / physiology
Hip Dislocation, Congenital / etiology
Humans
Iodine Radioisotopes / adverse effects,  therapeutic use*
Male
Pregnancy
Pregnancy Complications, Neoplastic / radiotherapy*
Radiation Injuries
Retrospective Studies
Thyroid Neoplasms / radiotherapy*
Trisomy
Ureteral Diseases / etiology
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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