Document Detail

Concept and evaluation of hibernating myocardium.
MedLine Citation:
PMID:  10073264     Owner:  NLM     Status:  MEDLINE    
Hibernating myocardium is a state of persistently impaired myocardial and left ventricular function at rest due to reduced coronary blood flows. It can be defined as an exquisitely regulated tissue successfully adapting its activity to prevailing circumstances. It has been documented in patients with angina (chronic stable and/or unstable), acute myocardial infarction, heart failure and/or severe left ventricular dysfunction, and anomalous left coronary artery from the pulmonary artery. The diagnosis of hibernating myocardium involves (a) documenting left ventricular dysfunction at rest and (b) documenting that there is viable myocardium in the area of dysfunction. Tests commonly used for the latter are dobutamine echocardiography, 201Tl isotope studies, and positron image tomography. Revascularization, either by surgery or by interventional catheter techniques, has been shown to improve or normalize the abnormal left ventricular function at rest.
S H Rahimtoola
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  50     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  1999  
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-86     Citation Subset:  IM    
Griffith Center, LAC + USC Medical Center, University of Southern California 90033, USA.
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MeSH Terms
Adaptation, Physiological
Angina Pectoris / complications
Angina, Unstable / complications
Cardiac Output, Low / complications
Chronic Disease
Coronary Circulation / physiology
Coronary Vessel Anomalies / complications
Myocardial Contraction / physiology
Myocardial Infarction / complications
Myocardial Revascularization
Myocardial Stunning / diagnosis,  etiology,  physiopathology*,  therapy
Myocardium / pathology
Pulmonary Artery / abnormalities
Radiopharmaceuticals / diagnostic use
Thallium Radioisotopes / diagnostic use
Tissue Survival
Tomography, Emission-Computed
Ventricular Dysfunction, Left / complications
Ventricular Function, Left / physiology
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Thallium Radioisotopes

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