Document Detail

Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals.
MedLine Citation:
PMID:  1503069     Owner:  NLM     Status:  MEDLINE    
Thiamin, thiamin monophosphate, ascorbic acid, and folic acid were determined in serum and cerebrospinal fluid (CSF) in 31 outpatients who underwent a myelography because of back-pain. All subjects were otherwise healthy. The CSF concentration (mean +/- SD) was 8.6 +/- 3.9 nmol thiamin/L, 16.9 +/- 8.3 nmol thiamin monophosphate/L, 133 +/- 58.8 mumol ascorbic acid/L, and 44.9 +/- 13.2 nmol folic acid/L. The CSF-serum ratio was 2.1 +/- 0.8 for thiamin, 8.3 +/- 4.3 for thiamin monophosphate, 3.0 +/- 1.4 for ascorbic acid, and 3.3 +/- 0.8 for folic acid; the amount in CSF was significantly higher than in serum for each compound. These results support the existence of a saturated transport mechanism of water-soluble vitamins from serum into CSF for thiamin monophosphate, ascorbic acid, and folic acid. However, low CSF concentrations are correlated with low serum concentrations for the three vitamins. High serum concentrations should therefore be advocated to ensure high CSF concentrations.
C M Tallaksen; T Bøhmer; H Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  56     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  AIM; IM    
Medical Department, Aker University Hospital, Oslo, Norway.
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MeSH Terms
Aged, 80 and over
Ascorbic Acid / blood*,  cerebrospinal fluid*
Folic Acid / blood*,  cerebrospinal fluid*
Middle Aged
Reference Values
Thiamine / blood*,  cerebrospinal fluid*
Reg. No./Substance:
50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 59-43-8/Thiamine

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