Document Detail

Concentrations of tocopherols and carotenoids in maternal and cord blood plasma.
MedLine Citation:
PMID:  10509767     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the levels of tocopherols, retinol and carotenoids in maternal and umbilical cord blood plasma and to investigate the relationships between them. DESIGN: Venous blood plasma concentrations of alpha, gamma and delta-tocopherol, retinol, lutein, lycopene, zeaxanthin, beta-cryptoxanthin, alpha and beta-carotene were determined by HPLC in healthy pregnant women and in pair-matched umbilical cords. Plasma levels of triglycerides and cholesterol were also measured. SUBJECTS: Sixty-six women, between 10 and 20 weeks gestation, were recruited randomly during their first antenatal appointment. From this group, 40 pair-matched umbilical cord blood samples were obtained. RESULTS: Tocopherols, retinol, carotenoids and lipids were present in significantly higher (P < 0.001) concentrations in maternal plasma than in cord plasma. There was a significant correlation (r = 0.45, P < 0.005) between maternal and cord levels of gamma-tocopherol, but not of alpha-tocopherol, retinol or carotenoids. Tocopherols and carotenoids were significantly correlated with each other (P < 0.05) in maternal and cord plasma. CONCLUSIONS: Plasma levels of tocopherols, carotenoids and lipids are substantially lower at birth than in adulthood. There is a clear relationship between gamma-tocopherol levels in maternal and cord plasma. The importance of gamma-tocopherol in human nutrition should be further investigated. There are no significant relationships between plasma alpha-tocopherol and carotenoids in pregnant mothers and cords. More research is needed to elucidate the maternal-foetal transfer of tocopherols and carotenoids, and to examine the impact of maternal antioxidant nutrient status on neonatal antioxidant capacity. It is important to determine if a low level of tocopherols and carotenoids at birth is a normal stage of human development or indicative of deficiency.
M Kiely; P F Cogan; P J Kearney; P A Morrissey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  53     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-16     Completed Date:  1999-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  711-5     Citation Subset:  IM    
Department of Nutrition, National Food Biotechnology Centre, University College, Cork, Ireland.
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MeSH Terms
Carotenoids / blood*
Cholesterol / blood
Chromatography, High Pressure Liquid
Fetal Blood / chemistry*
Gestational Age
Pregnancy / blood*
Triglycerides / blood
Vitamin E / blood*
Reg. No./Substance:
0/Triglycerides; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 57-88-5/Cholesterol

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