Document Detail


Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat.
MedLine Citation:
PMID:  6990719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine if the levels of TXA2 and PGI2 within the uterus change at parturition in rats, the concentrations of their respective stable products, TXB2 and 6-oxo-PGF1 alpha (6-k-PGF1 alpha) were measured in amniotic fluid, decidual and placental tissues by specific radioimmunoassays which have been verified by gas chromatography-mass spectrometry. Samples were collected on days 15, 20, 21, and 22 of pregnancy and during labor on day 23. In general, levels of TXB2 and 6-k-PGF1 alpha as well as those of PGE and PGF were highest during labor on day 23, although levels of TXB2 and 6-k-PGF1 alpha in amniotic fluid and decidual tissue, respectively, peaked on day 22. The concentrations were generally highest in decidual tissue, and lowest in amniotic fluid. These findings suggest that TXA2 and PGI2 may have a role in parturition in rats.
Authors:
J Zamecnik; T G Kennedy; D T Armstrong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in prostaglandin and thromboxane research     Volume:  8     ISSN:  0361-5952     ISO Abbreviation:  Adv Prostaglandin Thromboxane Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7610366     Medline TA:  Adv Prostaglandin Thromboxane Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1423-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxypregnenolone / blood
6-Ketoprostaglandin F1 alpha
Amniotic Fluid / metabolism*
Animals
Decidua / metabolism*
Epoprostenol / metabolism
Estradiol / blood
Female
Labor, Obstetric
Placenta / metabolism*
Pregnancy
Pregnancy, Animal*
Progesterone / blood
Prostaglandins F / metabolism*
Rats
Thromboxane A2 / metabolism
Thromboxane B2 / metabolism*
Thromboxanes / metabolism*
Chemical
Reg. No./Substance:
0/Prostaglandins F; 0/Thromboxanes; 35121-78-9/Epoprostenol; 387-79-1/17-alpha-Hydroxypregnenolone; 50-28-2/Estradiol; 54397-85-2/Thromboxane B2; 57-83-0/Progesterone; 57576-52-0/Thromboxane A2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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