Document Detail

Concentrations of progesterone, follistatin, and follicle-stimulating hormone in peripheral plasma across the estrous cycle and pregnancy in merino ewes that are homozygous or noncarriers of the Booroola gene.
MedLine Citation:
PMID:  12773419     Owner:  NLM     Status:  MEDLINE    
The circulating concentrations of progesterone, FSH, and follistatin across the estrous cycle and gestation were compared in Australian merino sheep that were homozygous for the Booroola gene, FecB, or were noncarriers. The Booroola phenotype is due to a point mutation in the bone morphogenetic protein receptor 1B. Progesterone concentrations began to rise earlier and were higher in the Booroola ewes than in the noncarriers on most days of the luteal phase but not during the follicular phase of the cycle. Follistatin concentrations remained unchanged across the estrous cycle in both groups of ewes, with no differences between genotypes. FSH concentrations were higher in Booroola ewes than in noncarrier ewes on most days of the estrous cycle, with a significantly higher and broader peak of FSH around the time of estrus. Progesterone concentrations were significantly higher in early and midgestation in Booroola ewes but were lower toward the end of gestation than those in noncarriers. FSH declined in both groups across gestation, with lower concentrations of FSH in Booroola ewes during midgestation. Follistatin remained unchanged across gestation in Booroola ewes and noncarrier ewes with a twin pregnancy but declined across gestation in noncarrier ewes with a singleton pregnancy. These results suggest that follistatin concentration is not regulated by the FecB gene during the estrous cycle and pregnancy but is influenced by the number of fetuses. However, the FecB gene appears to positively affect both progesterone and FSH during the estrous cycle and across pregnancy, which suggests that bone morphogenetic proteins play an important role in the regulation of both hormones.
Y Xia; T O'Shea; R Murison; J R McFarlane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-05-28
Journal Detail:
Title:  Biology of reproduction     Volume:  69     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2004-05-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1079-84     Citation Subset:  IM    
Department of Physiology, School of Biomedical, Biological & Molecular Sciences, University of New England, New South Wales, Australia.
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MeSH Terms
Bone Morphogenetic Protein Receptors, Type I
Estrous Cycle / blood*,  genetics
Fertility / genetics
Follicle Stimulating Hormone / blood*
Follistatin / blood*
Ovulation / blood,  genetics
Point Mutation
Pregnancy / blood*,  genetics
Progesterone / blood*
Protein-Serine-Threonine Kinases / genetics*
Receptors, Growth Factor / genetics*
Sheep / genetics*,  metabolism*
Reg. No./Substance:
0/Follistatin; 0/Receptors, Growth Factor; 57-83-0/Progesterone; 9002-68-0/Follicle Stimulating Hormone; EC Kinases; EC Morphogenetic Protein Receptors, Type I

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