Document Detail


Concentrations of progesterone, follistatin, and follicle-stimulating hormone in peripheral plasma across the estrous cycle and pregnancy in merino ewes that are homozygous or noncarriers of the Booroola gene.
MedLine Citation:
PMID:  12773419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The circulating concentrations of progesterone, FSH, and follistatin across the estrous cycle and gestation were compared in Australian merino sheep that were homozygous for the Booroola gene, FecB, or were noncarriers. The Booroola phenotype is due to a point mutation in the bone morphogenetic protein receptor 1B. Progesterone concentrations began to rise earlier and were higher in the Booroola ewes than in the noncarriers on most days of the luteal phase but not during the follicular phase of the cycle. Follistatin concentrations remained unchanged across the estrous cycle in both groups of ewes, with no differences between genotypes. FSH concentrations were higher in Booroola ewes than in noncarrier ewes on most days of the estrous cycle, with a significantly higher and broader peak of FSH around the time of estrus. Progesterone concentrations were significantly higher in early and midgestation in Booroola ewes but were lower toward the end of gestation than those in noncarriers. FSH declined in both groups across gestation, with lower concentrations of FSH in Booroola ewes during midgestation. Follistatin remained unchanged across gestation in Booroola ewes and noncarrier ewes with a twin pregnancy but declined across gestation in noncarrier ewes with a singleton pregnancy. These results suggest that follistatin concentration is not regulated by the FecB gene during the estrous cycle and pregnancy but is influenced by the number of fetuses. However, the FecB gene appears to positively affect both progesterone and FSH during the estrous cycle and across pregnancy, which suggests that bone morphogenetic proteins play an important role in the regulation of both hormones.
Authors:
Y Xia; T O'Shea; R Murison; J R McFarlane
Related Documents :
588179 - The effects of ct1341, thiopentone and induction- delivery time on the blood gas and ac...
6495569 - Pelvic dimensions, bodyweight and parturition in rare breeds of sheep.
9481519 - Losses due to porcine reproductive and respiratory syndrome in a large swine farm.
9621929 - Relationships among ewe milk production and ewe and lamb forage intake in suffolk and t...
1881979 - Importance of progesterone and estrogen priming for the induction of maternal behavior ...
24195779 - Integrating multiple 'omics' analyses identifies serological protein biomarkers for pre...
10584629 - Nonlinear analysis of biomagnetic signals recorded from the umbilical artery in normal ...
3605239 - A hypothesis concerning the general basis of organogenetic congenital anomalies.
21860279 - 17α-hydroxyprogesterone caproate for the prevention of adverse neonatal outcome in mult...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-05-28
Journal Detail:
Title:  Biology of reproduction     Volume:  69     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2004-05-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1079-84     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Biomedical, Biological & Molecular Sciences, University of New England, New South Wales, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bone Morphogenetic Protein Receptors, Type I
Estrous Cycle / blood*,  genetics
Female
Fertility / genetics
Follicle Stimulating Hormone / blood*
Follistatin / blood*
Genotype
Heterozygote
Homozygote
Ovulation / blood,  genetics
Periodicity
Point Mutation
Pregnancy / blood*,  genetics
Progesterone / blood*
Protein-Serine-Threonine Kinases / genetics*
Receptors, Growth Factor / genetics*
Sheep / genetics*,  metabolism*
Chemical
Reg. No./Substance:
0/Follistatin; 0/Receptors, Growth Factor; 57-83-0/Progesterone; 9002-68-0/Follicle Stimulating Hormone; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Production of cloned pigs by whole-cell intracytoplasmic microinjection.
Next Document:  Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the ...