Document Detail

Concentrations of pregnancy-specific beta 1-glycoprotein in maternal blood in normal pregnancy and in intrauterine growth retardation.
MedLine Citation:
PMID:  64859     Owner:  NLM     Status:  MEDLINE    
A radioimmunoassay has been developed for pregnancy-specific beta 1-glycoprotein (S.P.1), a product of the human placenta. Circulating concentrations of S.P.1 were measured in 153 women in the third trimester of normal pregnancy and in 27 women who delivered children with birth-weight below the 10th centile of the normal range--i.e., with intrauterine growth regardation (I.U.G.R.). Concentrations of S.P.1 showed a skewed distribution and rose progressively to reach a plateau in the last four weeks of pregnancy. In over 70% of women with I.U.G.R. of the fetus, concentrations of S.P.1 were low. Measurement of serum-S.P.1 may provide a new index of fetal wellbeing.
Y P Gordon; J G Grudzinskas; D Jeffrey; T Chard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2011-08-29    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Fetal Diseases / diagnosis*
Glycoproteins / blood*
Hypertension / blood
Infant, Newborn
Placenta Diseases / blood*
Placental Function Tests
Placental Insufficiency / blood*
Pregnancy Complications, Cardiovascular / blood
Pregnancy Trimester, Third
Reg. No./Substance:

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