| Concentrations of the major birch tree allergen Bet v 1 in pollen and respirable fine particles in the atmosphere. | |
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MedLine Citation:
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PMID: 9389296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Birch tree pollen allergens are an important cause of early spring hay fever and allergic asthma. Pollen counts provide a guide for individuals with birch pollen allergy. However, birch pollen, because of its size, has a low probability of entering the lower airways to trigger asthma. Yet birch pollen allergens are known to be associated with respirable particles present in the atmosphere. OBJECTIVE: We sought to determine the concentration of major allergen Bet v 1 in birch pollen and respirable particles in the atmosphere during the birch pollen season. METHODS: We used a two-site monoclonal antibody-based assay (ELISA) to quantitate Bet v 1 in pollen extracts and high-volume air sampler filters collecting particles larger and smaller than 7.2 microm. RESULTS: Bet v 1 (0.006 ng) is detectable per birch pollen grain, of which 0.004 ng is present in aqueous extracts (13.9% of soluble proteins). Atmospheric Bet v 1 concentrations are correlated with birch pollen counts. Heavy rainfall tended to wash out pollen and particles, indicated by a mean daily Bet v 1 concentration of 0.12 ng/m3 (20 pollen equivalents), but light rainfall produced a dramatic increase in allergen-loaded respirable particles with Bet v 1 concentrations of 1.2 ng/m3 (200 pollen equivalents). CONCLUSION: These results highlight the different environmental risk factors for hay fever and allergic asthma in patients sensitized to Bet v 1. Light rainfall causes an increase in respirable particles; hence, this is an important risk factor for asthma. |
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Authors:
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G F Schäppi; C Suphioglu; P E Taylor; R B Knox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 100 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-05 Completed Date: 1998-01-05 Revised Date: 2011-06-21 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 656-61 Citation Subset: AIM; IM |
Affiliation:
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Pollen and Allergen Research Group, School of Botany, The University of Melbourne, Parkville, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollution
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analysis Allergens / analysis* Antigens, Plant Cell Count Filtration / instrumentation Humans Plant Proteins / analysis* Pollen / chemistry*, cytology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antigens, Plant; 0/Plant Proteins; 126161-14-6/Bet v 1 allergen, Betula |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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