Document Detail

Concentrations of interleukin-1 beta, interleukin-6, interleukin-8 and TNF-alpha in cerebrospinal fluid from children with septic or aseptic meningitis.
MedLine Citation:
PMID:  1305908     Owner:  NLM     Status:  MEDLINE    
Cytokines at an inflammatory site may be a better indicator of the clinical severity of an infectious disease than the serum levels of the cytokines. Concentrations of interleukin-1 beta (IL-1 beta) in paired samples of cerebrospinal fluid (CSF) from 10 rabbits with experimental bacterial meningitis caused by H. influenzae type b, were measured, and compared to the concentrations of four cytokines; IL-1 beta, interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) in CSF samples from 45 children with or without meningitis. The IL-1 beta concentrations in the CSF from rabbits with experimental meningitis were significantly higher than the concentrations in control animals without meningitis (p < 0.001). The mean CSF concentrations of IL-8 from meningitic children were significantly higher than in the control group without meningitis (p < 0.005). TNF-alpha was only detected in septic meningitis. Assays of IL-6, however, were not significantly different in the septic meningitis group, the aseptic meningitis group and the non-meningitis group. These data indicate a possible role of IL-1 beta, IL-8 and TNF-alpha as mediators in the meningeal inflammatory process in patients with meningitis and TNF-alpha, in particular, may play a role in the pathogenesis of septic meningitis.
S Handa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Kurume medical journal     Volume:  39     ISSN:  0023-5679     ISO Abbreviation:  Kurume Med J     Publication Date:  1992  
Date Detail:
Created Date:  1993-07-27     Completed Date:  1993-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985210R     Medline TA:  Kurume Med J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  257-65     Citation Subset:  IM    
Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
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MeSH Terms
Child, Preschool
Interleukin-1 / cerebrospinal fluid*
Interleukin-6 / cerebrospinal fluid*
Interleukin-8 / cerebrospinal fluid*
Meningitis, Aseptic / cerebrospinal fluid*
Meningitis, Bacterial / cerebrospinal fluid*
Tumor Necrosis Factor-alpha / cerebrospinal fluid*
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha

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