Document Detail

Concentrations of free vascular endothelial growth factor in the maternal and foetal circulations during pregnancy: a cross-sectional study.
MedLine Citation:
PMID:  20044875     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the concentrations of free plasma vascular endothelial growth factor (VEGF) in the maternal and foetal circulations of normal term pregnancies.
METHODS: Free plasma VEGF was measured from plasma of umbilical cord and maternal blood by ELISA for each of 20 normal pregnancies delivering at term at an altitude of 3100 m. Spearman's correlation coefficient was used to test for correlation between values and clinical maternal and neonatal data. Student's 't' test was used to test for differences between samples from male and female neonates.
RESULTS: Free plasma VEGF was undetectable from maternal samples, but it was detectable in the cord blood (mean, 560.3775 pg/ml, median, 145.84 pg/ml, range, 22.56-2653.5). No differences were found between neonates sex, and no correlation was found with clinical maternal and neonatal data.
CONCLUSION: Circulating VEGF is usually bound to the soluble form of its receptor 1 (sFlt-1). High levels of sFlt-1 are secreted by the syncytiotrophoblast during pregnancy, and so free plasma VEGF is undetectable in the maternal circulation. In contrast, our findings are the first to show free plasma VEGF in the umbilical circulation. We speculate that this free VEGF may promote angiogenesis in the foetus and placenta. Our data imply that sFlt-1 is not present in the cord blood, and that secretion by the syncytiotrophoblast is polarised to its apical surface. Further investigations are required to test this hypothesis.
Kamal Z Ali; Graham J Burton; Mohammed E Khalid; Riyad Moosa; Salah Abd-Alla
Related Documents :
2905305 - Criteria for the oral glucose tolerance test in pregnant and non-pregnant nigerian women.
2311815 - Influence of parity on plasma lipid levels.
16487435 - Apolipoprotein e genotype is related to plasma levels of c-reactive protein and lipids ...
23111115 - Maternal azithromycin therapy for ureaplasma intraamniotic infection delays preterm del...
24242075 - Reproductive issues in adults with cystic fibrosis: implications for genetic counseling.
12576745 - Elevated second-trimester maternal serum inhibin a levels in asian pregnancies with fet...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1244-8     Citation Subset:  IM    
Department of Anatomy, King Khalid University, College of Medicine, Abha, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cross-Sectional Studies
Fetal Blood / chemistry*
Infant, Newborn
Vascular Endothelial Growth Factor A / blood*
Reg. No./Substance:
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The co-occurrence of intimate partner violence and syphilis among pregnant women in Bolivia.
Next Document:  Umbilical vein blood flow at 11 + 0 to 13 + 6 weeks of gestation.