Document Detail


Concentrations of antioxidant vitamins in maternal and cord serum and their effect on birth outcomes.
MedLine Citation:
PMID:  19352057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in maintaining physiological processes of pregnancy and growth. AIMS: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. METHODS: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. RESULTS: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight (r=0.19, p=0.0419) and birth height (r=0.21, p=0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 micromol/L increase in maternal serum vitamin A level (p<0.01; 95% CI: 56.9-451.5); and (ii) per 1% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height (p=0.049; 95% CI: 0.004-1.639). CONCLUSION: Maternal vitamin A, but not vitamins E and C, during pregnancy had a significant effect on birth outcomes. Further studies are necessary to investigate the role of these antioxidant vitamins in fetal growth at various gestation stages.
Authors:
Yong-Zhong Wang; Wei-Hong Ren; Wen-qiang Liao; Guo-Yuan Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  55     ISSN:  1881-7742     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Third People's Hospital, Changzhou, Jiangsu Province, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / analysis*
Ascorbic Acid / blood
Birth Weight*
Blood Chemical Analysis
Body Height
China
Cross-Sectional Studies
Female
Fetal Blood / chemistry*
Fetal Development*
Humans
Infant, Newborn / blood*
Male
Oxidative Stress
Pregnancy
Prenatal Nutritional Physiological Phenomena*
Vitamin A / blood
Vitamin E / blood
Vitamins / blood*
Young Adult
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

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