| The concentrations of markers of bone turnover in normal pregnancy and preeclampsia. | |
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MedLine Citation:
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PMID: 20822429 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background. The purpose of our study was to investigate the concentrations of markers of bone turnover in normal pregnancy and preeclampsia. Material and Methods. Forty-five pregnant patients with preeclampsia, 78 healthy pregnant women (26 in first, 26 in the second, and 26 in third trimester of pregnancy), and 20 nonpregnant women were included in the study. Serum concentrations of osteoprotegrin (OPG), receptor activator of nuclear factor kappa B ligand (sRANKL), and the markers of bone turnover, osteocalcin and CrossLaps-degradation products of type I collagen, were determined using the ELISA method. Statistical analysis was performed using Mann-Whitney U-test. Results. The concentrations of sRANKL and OPG were significantly higher in the second trimester of normal pregnancy when compared to the first and the third trimesters and to nonpregnant controls. The concentrations of osteocalcin were significantly higher in the first trimester of physiological pregnancy in comparison with nonpregnant women and with second and third trimesters of pregnancy. The concentrations of CrossLaps were significantly higher in the second trimester of normal pregnancy when compared to the first and third trimester. In preeclampsia, the sera concentrations of osteocalcin and CrossLaps were significantly higher when compared to the third trimester of normal pregnancy. Conclusion. The results suggest that the bone formation is increased in the first trimester, whereas the bone resorption is increased in the second trimester of normal pregnancy. Furthermore, the results suggest that the bone turnover is increased in patients with preeclampsia when compared to healthy normotensive pregnant women. |
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Authors:
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Darmochwal-Kolarz Dorota; Kolarz G Bogdan; Gorzelak Mieczyslaw; Leszczynska-Gorzelak Bozena; Oleszczuk Jan |
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Publication Detail:
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Type: Journal Article Date: 2010-09-07 |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 31 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 166-76 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Perinatology, Medical University of Lublin , Lublin, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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