Document Detail

Concentrations of inflammatory cytokines and the outcome in ICSI cycles.
MedLine Citation:
PMID:  20668315     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to measure circulating and intrafollicular concentrations of three inflammatory cytokines from women undergoing ovarian stimulation in order to determine their prognostic value in the outcome of intracytoplasmic sperm injection/embryo transfer cycles. MATERIALS AND METHODS: A total of 72 women following ovarian stimulation and intracytoplasmic sperm injection were included. Blood serum samples were drawn at the day of chorionic gonadotropin administration. Follicular fluids were collected at the day of oocyte retrieval. The total fractions of tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6 were measured with commercially available immunoassays. RESULTS: The concentrations of IL-1beta, both in serum and follicular fluids, were significantly different between ICSI cycles that resulted in pregnancy and those that failed. The concentrations of the other two cytokines did not significantly differ between successful and unsuccessful cycles. CONCLUSION: The circulating and intrafollicular concentrations of IL-1beta seem to be related to the pregnancy outcome in ICSI cycles of healthy women.
Byron Asimakopoulos; Cem Demirel; Ricardo Felberbaum; Steven Waczek; Nikos Nikolettos; Frank Köster; Safaa Al-Hasani; Klaus Diedrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  24     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
IVF Unit, General University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin / therapeutic use
Cytokines / blood*
Embryo Transfer
Estradiol / blood
Follicle Stimulating Hormone / blood
Hormones / blood
Menstrual Cycle
Ovulation Induction
Patient Selection
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Cytokines; 0/Hormones; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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